Pulsed photoacoustic study of the diffusion of chromophores in human skin

F. Lahjomri, G. Puccetti, R. M. Leblanc, V. Alard, A. Denis, J. F. Tranchant

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The technique of pulsed photoacoustic spectroscopy was used to investigate the diffusion of chromophores in human skin. The kinetic of diffusion has been studied for five solutions at different concentrations in a mixture of chromophores, as used in commercial sunscreens. In addition to the classical macroscopic interpretation of the diffusion process, a new method is shown to give more detailed information on chromophore presence at different depths in skin. For the first time, results are expressed in the frequency domain by means of the Fourier transform applied to the photoacoustic signal. The spectra are discussed versus the depth in skin samples and the time of diffusion kinetics. This new method of data analysis is shown to be very useful for understanding the influence of the internal structure of a medium on the penetration rate of chromophores into skin.

Original languageEnglish (US)
Pages (from-to)292-302
Number of pages11
JournalPhotochemistry and Photobiology
Volume65
Issue number2
DOIs
StatePublished - Feb 1997

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry

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