Pulsed infrared radiation leads to synchronous contraction in stem cell derived cardiomyocytes

Jordan M. Greenberg; Suhrud M. Rajguru; Daniel Pelaez; Herman S. Cheung

doi:10.1109/SBEC.2013.61

Pulsed infrared radiation leads to synchronous contraction in stem cell derived cardiomyocytes

Jordan M. Greenberg, Suhrud M. Rajguru, Daniel Pelaez, Herman S. Cheung

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

Adult stem cell derived cardiomyocyte research has been limited by the inability of these cells to fully mature into fully functioning cardiomyocytes. Although these cells exhibit correct gene expression and protein production, they do not spontaneously contract as seen in vivo. Several methods are currently being investigated to stimulate the contraction of these cells in vitro. We investigated a method which uses pulsed infrared radiation (IR) to induce contraction. Through a mitochondrial calcium flux we were able to induce contraction in these cells. Although successful in stimulating contraction, the location of calcium release and absence of continuous contraction has led us to believe that a more physiological method of stimulating these cells is required for future studies.

Original language	English (US)
Title of host publication	Proceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013
Pages	105-106
Number of pages	2
DOIs	https://doi.org/10.1109/SBEC.2013.61
State	Published - Aug 5 2013
Event	29th Southern Biomedical Engineering Conference, SBEC 2013 - Miami, FL, United States Duration: May 3 2013 → May 5 2013

Publication series

Name	Proceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013

Other

Other	29th Southern Biomedical Engineering Conference, SBEC 2013
Country	United States
City	Miami, FL
Period	5/3/13 → 5/5/13

ASJC Scopus subject areas

Biomedical Engineering

Access to Document

10.1109/SBEC.2013.61

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Greenberg, J. M., Rajguru, S. M., Pelaez, D., & Cheung, H. S. (2013). Pulsed infrared radiation leads to synchronous contraction in stem cell derived cardiomyocytes. In Proceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013 (pp. 105-106). [6525698] (Proceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013). https://doi.org/10.1109/SBEC.2013.61

Pulsed infrared radiation leads to synchronous contraction in stem cell derived cardiomyocytes. / Greenberg, Jordan M.; Rajguru, Suhrud M.; Pelaez, Daniel ; Cheung, Herman S.

Proceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013. 2013. p. 105-106 6525698 (Proceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Greenberg, JM, Rajguru, SM , Pelaez, D & Cheung, HS 2013, Pulsed infrared radiation leads to synchronous contraction in stem cell derived cardiomyocytes. in Proceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013., 6525698, Proceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013, pp. 105-106, 29th Southern Biomedical Engineering Conference, SBEC 2013, Miami, FL, United States, 5/3/13. https://doi.org/10.1109/SBEC.2013.61

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