TY - GEN
T1 - Pulsed infrared radiation leads to synchronous contraction in stem cell derived cardiomyocytes
AU - Greenberg, Jordan M.
AU - Rajguru, Suhrud M.
AU - Pelaez, Daniel
AU - Cheung, Herman S.
PY - 2013/8/5
Y1 - 2013/8/5
N2 - Adult stem cell derived cardiomyocyte research has been limited by the inability of these cells to fully mature into fully functioning cardiomyocytes. Although these cells exhibit correct gene expression and protein production, they do not spontaneously contract as seen in vivo. Several methods are currently being investigated to stimulate the contraction of these cells in vitro. We investigated a method which uses pulsed infrared radiation (IR) to induce contraction. Through a mitochondrial calcium flux we were able to induce contraction in these cells. Although successful in stimulating contraction, the location of calcium release and absence of continuous contraction has led us to believe that a more physiological method of stimulating these cells is required for future studies.
AB - Adult stem cell derived cardiomyocyte research has been limited by the inability of these cells to fully mature into fully functioning cardiomyocytes. Although these cells exhibit correct gene expression and protein production, they do not spontaneously contract as seen in vivo. Several methods are currently being investigated to stimulate the contraction of these cells in vitro. We investigated a method which uses pulsed infrared radiation (IR) to induce contraction. Through a mitochondrial calcium flux we were able to induce contraction in these cells. Although successful in stimulating contraction, the location of calcium release and absence of continuous contraction has led us to believe that a more physiological method of stimulating these cells is required for future studies.
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U2 - 10.1109/SBEC.2013.61
DO - 10.1109/SBEC.2013.61
M3 - Conference contribution
AN - SCOPUS:84880886302
SN - 9780769550329
T3 - Proceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013
SP - 105
EP - 106
BT - Proceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013
T2 - 29th Southern Biomedical Engineering Conference, SBEC 2013
Y2 - 3 May 2013 through 5 May 2013
ER -