Pulsed infrared-evoked intracellular calcium transients in neonatal vestibular and spiral ganglion neurons

Vicente Lumbreras, Esperanza Bas Infante, Chhavi Gupta, Suhrud M Rajguru

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Pulsed infrared radiation (IR) has been shown to have high spatial selectivity and could potentially be used in auditory and vestibular prostheses. Results from stimulation of cardiomyocytes suggest that pulsed IR evokes intracellular Ca2+ responses. In the present study, we analyzed the response of rat neonatal vestibular and spiral ganglion neurons to infrared radiation (IR), λ = 1863 nm, in vitro. Both types of neurons responded with intracellular [Ca2+]i transients that could be entrained by the low frequency IR pulses (0.25-5 pulses/s). When challenged with an inhibitor of the mitochondrial Na+/Ca2+ exchanger (CGP-37157) and a blocker of mitochondrial Ca2+ uniporter (Ruthenium Red), the IR-evoked responses were blocked or significantly reduced. This suggest that mitochondrial [Ca2+]iflux may be a primary source of the IR transients.

Original languageEnglish
Title of host publicationProceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013
Pages101-102
Number of pages2
DOIs
StatePublished - Aug 5 2013
Event29th Southern Biomedical Engineering Conference, SBEC 2013 - Miami, FL, United States
Duration: May 3 2013May 5 2013

Other

Other29th Southern Biomedical Engineering Conference, SBEC 2013
CountryUnited States
CityMiami, FL
Period5/3/135/5/13

Fingerprint

Neurons
Calcium
Infrared radiation
Prosthetics
Ruthenium
Rats

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Lumbreras, V., Bas Infante, E., Gupta, C., & Rajguru, S. M. (2013). Pulsed infrared-evoked intracellular calcium transients in neonatal vestibular and spiral ganglion neurons. In Proceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013 (pp. 101-102). [6525696] https://doi.org/10.1109/SBEC.2013.59

Pulsed infrared-evoked intracellular calcium transients in neonatal vestibular and spiral ganglion neurons. / Lumbreras, Vicente; Bas Infante, Esperanza; Gupta, Chhavi; Rajguru, Suhrud M.

Proceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013. 2013. p. 101-102 6525696.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Lumbreras, V, Bas Infante, E, Gupta, C & Rajguru, SM 2013, Pulsed infrared-evoked intracellular calcium transients in neonatal vestibular and spiral ganglion neurons. in Proceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013., 6525696, pp. 101-102, 29th Southern Biomedical Engineering Conference, SBEC 2013, Miami, FL, United States, 5/3/13. https://doi.org/10.1109/SBEC.2013.59
Lumbreras V, Bas Infante E, Gupta C, Rajguru SM. Pulsed infrared-evoked intracellular calcium transients in neonatal vestibular and spiral ganglion neurons. In Proceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013. 2013. p. 101-102. 6525696 https://doi.org/10.1109/SBEC.2013.59
Lumbreras, Vicente ; Bas Infante, Esperanza ; Gupta, Chhavi ; Rajguru, Suhrud M. / Pulsed infrared-evoked intracellular calcium transients in neonatal vestibular and spiral ganglion neurons. Proceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013. 2013. pp. 101-102
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