Pulsed infrared-evoked intracellular calcium transients in neonatal vestibular and spiral ganglion neurons

Vicente Lumbreras; Esperanza Bas; Chhavi Gupta; Suhrud M. Rajguru

doi:10.1109/SBEC.2013.59

Pulsed infrared-evoked intracellular calcium transients in neonatal vestibular and spiral ganglion neurons

Vicente Lumbreras, Esperanza Bas, Chhavi Gupta, Suhrud M. Rajguru

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

Pulsed infrared radiation (IR) has been shown to have high spatial selectivity and could potentially be used in auditory and vestibular prostheses. Results from stimulation of cardiomyocytes suggest that pulsed IR evokes intracellular Ca²⁺ responses. In the present study, we analyzed the response of rat neonatal vestibular and spiral ganglion neurons to infrared radiation (IR), λ = 1863 nm, in vitro. Both types of neurons responded with intracellular [Ca²⁺]i transients that could be entrained by the low frequency IR pulses (0.25-5 pulses/s). When challenged with an inhibitor of the mitochondrial Na⁺/Ca²⁺ exchanger (CGP-37157) and a blocker of mitochondrial Ca²⁺ uniporter (Ruthenium Red), the IR-evoked responses were blocked or significantly reduced. This suggest that mitochondrial [Ca²⁺]_iflux may be a primary source of the IR transients.

Original language	English (US)
Title of host publication	Proceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013
Pages	101-102
Number of pages	2
DOIs	https://doi.org/10.1109/SBEC.2013.59
State	Published - Aug 5 2013
Event	29th Southern Biomedical Engineering Conference, SBEC 2013 - Miami, FL, United States Duration: May 3 2013 → May 5 2013

Publication series

Name	Proceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013

Other

Other	29th Southern Biomedical Engineering Conference, SBEC 2013
Country	United States
City	Miami, FL
Period	5/3/13 → 5/5/13

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ASJC Scopus subject areas

Biomedical Engineering

Cite this

Lumbreras, V., Bas, E., Gupta, C., & Rajguru, S. M. (2013). Pulsed infrared-evoked intracellular calcium transients in neonatal vestibular and spiral ganglion neurons. In Proceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013 (pp. 101-102). [6525696] (Proceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013). https://doi.org/10.1109/SBEC.2013.59

Pulsed infrared-evoked intracellular calcium transients in neonatal vestibular and spiral ganglion neurons. / Lumbreras, Vicente; Bas, Esperanza; Gupta, Chhavi; Rajguru, Suhrud M.

Proceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013. 2013. p. 101-102 6525696 (Proceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Lumbreras, V, Bas, E, Gupta, C & Rajguru, SM 2013, Pulsed infrared-evoked intracellular calcium transients in neonatal vestibular and spiral ganglion neurons. in Proceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013., 6525696, Proceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013, pp. 101-102, 29th Southern Biomedical Engineering Conference, SBEC 2013, Miami, FL, United States, 5/3/13. https://doi.org/10.1109/SBEC.2013.59

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Access to Document

10.1109/SBEC.2013.59