Pulsed infrared-evoked intracellular calcium transients in neonatal vestibular and spiral ganglion neurons

Vicente Lumbreras, Esperanza Bas, Chhavi Gupta, Suhrud M. Rajguru

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Pulsed infrared radiation (IR) has been shown to have high spatial selectivity and could potentially be used in auditory and vestibular prostheses. Results from stimulation of cardiomyocytes suggest that pulsed IR evokes intracellular Ca2+ responses. In the present study, we analyzed the response of rat neonatal vestibular and spiral ganglion neurons to infrared radiation (IR), λ = 1863 nm, in vitro. Both types of neurons responded with intracellular [Ca2+]i transients that could be entrained by the low frequency IR pulses (0.25-5 pulses/s). When challenged with an inhibitor of the mitochondrial Na+/Ca2+ exchanger (CGP-37157) and a blocker of mitochondrial Ca2+ uniporter (Ruthenium Red), the IR-evoked responses were blocked or significantly reduced. This suggest that mitochondrial [Ca2+]iflux may be a primary source of the IR transients.

Original languageEnglish (US)
Title of host publicationProceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013
Pages101-102
Number of pages2
DOIs
StatePublished - Aug 5 2013
Event29th Southern Biomedical Engineering Conference, SBEC 2013 - Miami, FL, United States
Duration: May 3 2013May 5 2013

Publication series

NameProceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013

Other

Other29th Southern Biomedical Engineering Conference, SBEC 2013
CountryUnited States
CityMiami, FL
Period5/3/135/5/13

ASJC Scopus subject areas

  • Biomedical Engineering

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    Lumbreras, V., Bas, E., Gupta, C., & Rajguru, S. M. (2013). Pulsed infrared-evoked intracellular calcium transients in neonatal vestibular and spiral ganglion neurons. In Proceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013 (pp. 101-102). [6525696] (Proceedings - 29th Southern Biomedical Engineering Conference, SBEC 2013). https://doi.org/10.1109/SBEC.2013.59