Pulsed dye laser-resistant port-wine stains

Mechanisms of resistance and implications for treatment

J. A. Savas, J. A. Ledon, K. Franca, A. Chacon, Keyvan Nouri

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Port-wine stains (PWS) are among the most common congenital vascular malformations. Unlike capillary haemangiomas, these lesions do not involute spontaneously but rather become progressively more disfiguring as the patient ages. While benign in nature, the cosmetic deformity and attendant psychological and emotional distress prompt the majority of those afflicted to seek treatment. The pulsed dye laser (PDL) has long been considered the treatment of choice for these vascular lesions; however, very few patients achieve total clearance with PDL therapy and a significant number of lesions fail to respond at all. In order to address these recalcitrant cases, the mechanisms that contribute to treatment resistance must be understood and novel laser and light therapies must be employed. This review will address what is currently known about lesion-specific characteristics of PDL-resistant PWS as well as discuss current and future treatment options.

Original languageEnglish
Pages (from-to)941-953
Number of pages13
JournalBritish Journal of Dermatology
Volume168
Issue number5
DOIs
StatePublished - May 1 2013

Fingerprint

Port-Wine Stain
Dye Lasers
Laser Therapy
Capillary Hemangioma
Vascular Malformations
Phototherapy
Therapeutics
Cosmetics
Blood Vessels
Psychology

ASJC Scopus subject areas

  • Dermatology

Cite this

Pulsed dye laser-resistant port-wine stains : Mechanisms of resistance and implications for treatment. / Savas, J. A.; Ledon, J. A.; Franca, K.; Chacon, A.; Nouri, Keyvan.

In: British Journal of Dermatology, Vol. 168, No. 5, 01.05.2013, p. 941-953.

Research output: Contribution to journalArticle

Savas, J. A. ; Ledon, J. A. ; Franca, K. ; Chacon, A. ; Nouri, Keyvan. / Pulsed dye laser-resistant port-wine stains : Mechanisms of resistance and implications for treatment. In: British Journal of Dermatology. 2013 ; Vol. 168, No. 5. pp. 941-953.
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