Abstract
Left ventricular hypertrophy was created in 15 pigs by banding the ascending aorta when they were young. The adult animals were placed on normothermic cardiopulmonary bypass and perfused with either nonpulsatile (two groups of pigs) or pulsatile (one group) flows. As long as the perfusion rate was maintained at 70 ml/kg/min, myocardial blood flow distribution, as determined by radioactive microspheres, was identical in the hearts with normal sinus rhythm and those with ventricular fibrillation irrespective of the type of perfusion. At low flow rates, however, subendocardial ischemia developed in all three groups, but was most severe in the fibrillating hearts, and was not reversed by pulsatile perfusion.
| Original language | English |
|---|---|
| Pages (from-to) | 559-563 |
| Number of pages | 5 |
| Journal | Annals of Thoracic Surgery |
| Volume | 27 |
| Issue number | 6 |
| State | Published - Dec 1 1979 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Surgery
Cite this
Pulsatile perfusion : Its effects on blood flow distribution in hypertrophied hearts. / Salerno, Tomas; Shizgal, H. M.; Dobell, A. R C.
In: Annals of Thoracic Surgery, Vol. 27, No. 6, 01.12.1979, p. 559-563.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pulsatile perfusion
T2 - Its effects on blood flow distribution in hypertrophied hearts
AU - Salerno, Tomas
AU - Shizgal, H. M.
AU - Dobell, A. R C
PY - 1979/12/1
Y1 - 1979/12/1
N2 - Left ventricular hypertrophy was created in 15 pigs by banding the ascending aorta when they were young. The adult animals were placed on normothermic cardiopulmonary bypass and perfused with either nonpulsatile (two groups of pigs) or pulsatile (one group) flows. As long as the perfusion rate was maintained at 70 ml/kg/min, myocardial blood flow distribution, as determined by radioactive microspheres, was identical in the hearts with normal sinus rhythm and those with ventricular fibrillation irrespective of the type of perfusion. At low flow rates, however, subendocardial ischemia developed in all three groups, but was most severe in the fibrillating hearts, and was not reversed by pulsatile perfusion.
AB - Left ventricular hypertrophy was created in 15 pigs by banding the ascending aorta when they were young. The adult animals were placed on normothermic cardiopulmonary bypass and perfused with either nonpulsatile (two groups of pigs) or pulsatile (one group) flows. As long as the perfusion rate was maintained at 70 ml/kg/min, myocardial blood flow distribution, as determined by radioactive microspheres, was identical in the hearts with normal sinus rhythm and those with ventricular fibrillation irrespective of the type of perfusion. At low flow rates, however, subendocardial ischemia developed in all three groups, but was most severe in the fibrillating hearts, and was not reversed by pulsatile perfusion.
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M3 - Article
C2 - 156526
AN - SCOPUS:0018486212
VL - 27
SP - 559
EP - 563
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
SN - 0003-4975
IS - 6
ER -