Pulmonary oxygen toxicity

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

Although oxygen therapy has been used in the care of critically ill patients for many years, the recognition of pulmonary oxygen toxicity as an important clinical problem is relatively recent. The biochemical basis of oxygen toxicity is increased production of highly reactive, partially reduced metabolites of oxygen, including hydrogen peroxide and free radicals, by cells in hyperoxia. Enzymatic intracellular defense mechanisms exist which protect cells from the toxic effects of oxygen free radicals. The physiologic manifestations of oxygen toxicity include decreases in vital capacity, diffusing capacity, and lung compliance. The pathologic changes of oxygen toxicity are not specific and resemble those of the adult respiratory distress syndrome. Many drugs used in the care of patients, including bleomycin, nitrofurantoin, and corticosteroids, may exacerbate oxygen-induced lung injury. No effective pharmacologic means exist for lessening pulmonary oxygen toxicity in humans.

Original languageEnglish
Pages (from-to)900-905
Number of pages6
JournalChest
Volume88
Issue number6
StatePublished - Dec 1 1985
Externally publishedYes

Fingerprint

Oxygen
Lung
Free Radicals
Lung Compliance
Nitrofurantoin
Hyperoxia
Poisons
Vital Capacity
Adult Respiratory Distress Syndrome
Bleomycin
Lung Injury
Critical Illness
Hydrogen Peroxide
Reactive Oxygen Species
Patient Care
Adrenal Cortex Hormones
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Jackson, R. (1985). Pulmonary oxygen toxicity. Chest, 88(6), 900-905.

Pulmonary oxygen toxicity. / Jackson, Robert.

In: Chest, Vol. 88, No. 6, 01.12.1985, p. 900-905.

Research output: Contribution to journalArticle

Jackson, R 1985, 'Pulmonary oxygen toxicity', Chest, vol. 88, no. 6, pp. 900-905.
Jackson R. Pulmonary oxygen toxicity. Chest. 1985 Dec 1;88(6):900-905.
Jackson, Robert. / Pulmonary oxygen toxicity. In: Chest. 1985 ; Vol. 88, No. 6. pp. 900-905.
@article{6d8901fe15e04e33bf9f322718df4e67,
title = "Pulmonary oxygen toxicity",
abstract = "Although oxygen therapy has been used in the care of critically ill patients for many years, the recognition of pulmonary oxygen toxicity as an important clinical problem is relatively recent. The biochemical basis of oxygen toxicity is increased production of highly reactive, partially reduced metabolites of oxygen, including hydrogen peroxide and free radicals, by cells in hyperoxia. Enzymatic intracellular defense mechanisms exist which protect cells from the toxic effects of oxygen free radicals. The physiologic manifestations of oxygen toxicity include decreases in vital capacity, diffusing capacity, and lung compliance. The pathologic changes of oxygen toxicity are not specific and resemble those of the adult respiratory distress syndrome. Many drugs used in the care of patients, including bleomycin, nitrofurantoin, and corticosteroids, may exacerbate oxygen-induced lung injury. No effective pharmacologic means exist for lessening pulmonary oxygen toxicity in humans.",
author = "Robert Jackson",
year = "1985",
month = "12",
day = "1",
language = "English",
volume = "88",
pages = "900--905",
journal = "Chest",
issn = "0012-3692",
publisher = "American College of Chest Physicians",
number = "6",

}

TY - JOUR

T1 - Pulmonary oxygen toxicity

AU - Jackson, Robert

PY - 1985/12/1

Y1 - 1985/12/1

N2 - Although oxygen therapy has been used in the care of critically ill patients for many years, the recognition of pulmonary oxygen toxicity as an important clinical problem is relatively recent. The biochemical basis of oxygen toxicity is increased production of highly reactive, partially reduced metabolites of oxygen, including hydrogen peroxide and free radicals, by cells in hyperoxia. Enzymatic intracellular defense mechanisms exist which protect cells from the toxic effects of oxygen free radicals. The physiologic manifestations of oxygen toxicity include decreases in vital capacity, diffusing capacity, and lung compliance. The pathologic changes of oxygen toxicity are not specific and resemble those of the adult respiratory distress syndrome. Many drugs used in the care of patients, including bleomycin, nitrofurantoin, and corticosteroids, may exacerbate oxygen-induced lung injury. No effective pharmacologic means exist for lessening pulmonary oxygen toxicity in humans.

AB - Although oxygen therapy has been used in the care of critically ill patients for many years, the recognition of pulmonary oxygen toxicity as an important clinical problem is relatively recent. The biochemical basis of oxygen toxicity is increased production of highly reactive, partially reduced metabolites of oxygen, including hydrogen peroxide and free radicals, by cells in hyperoxia. Enzymatic intracellular defense mechanisms exist which protect cells from the toxic effects of oxygen free radicals. The physiologic manifestations of oxygen toxicity include decreases in vital capacity, diffusing capacity, and lung compliance. The pathologic changes of oxygen toxicity are not specific and resemble those of the adult respiratory distress syndrome. Many drugs used in the care of patients, including bleomycin, nitrofurantoin, and corticosteroids, may exacerbate oxygen-induced lung injury. No effective pharmacologic means exist for lessening pulmonary oxygen toxicity in humans.

UR - http://www.scopus.com/inward/record.url?scp=0022406253&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022406253&partnerID=8YFLogxK

M3 - Article

C2 - 3905287

AN - SCOPUS:0022406253

VL - 88

SP - 900

EP - 905

JO - Chest

JF - Chest

SN - 0012-3692

IS - 6

ER -