Pulmonary function in preterm infants whose lungs were ventilated conventionally or by high-frequency oscillation

Tilo Gerhardt, Linda Reifenberg, Ronald N. Goldberg, Eduardo Bancalari

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

To test the hypothesis that high-frequency ventilation may reduce the risk of barotrauma and thus the incidence of chronic pulmonary damage in preterm infants who need mechanical ventilation, we measured lung function before discharge in 53 infants who needed mechanical ventilation on the first day after birth and were randomly assigned to receive intermittent mandatory ventilation (n=26) or to receive high-frequency oscillatory ventilation (n=27). There were no significant differences between the groups in birth weight (mean ±SD: 1010±240 vs 1030±230 gm), gestational age (29.1±2.0 vs 28.9±2.1 weeks), initial ventilatory support (mean airway pressure 7.2±1.8 vs 8.1±2.1 cm H2O; Flo2 0.62±0.24 vs 0.75±0.22), duration of mechanical ventilation (median (range): 6 (1 to 61) vs 10 (1 to 50) days) and duration of oxygen therapy (13 (1 to 109) vs 27 (4 to 227) days) for the intermittent mandatory ventilation group and the high-frequency oscillatory ventilation group, respectively. At the time of testing, weight was 1830±340 vs 1830±290 gm, and age was 68±24 vs 70±31 days. Respiratory flows were determined by pneumotachygraphy, esophageal pressure through a water-filled feeding tube, and functional residual capacity by N2 washout. Both groups had abnormal lung function with decreased lung compliance (1.65±0.51 vs 1.54±0.36 ml/cm H2O) and elevated pulmonary resistance (102±24 vs 107±36 cm H2O/L/sec). Functional residual capacity was in the normal range (30.6±6.0 vs 28.2±10.7 ml) in both groups. There were no significant differences in lung function between the two treatment groups. These results do not support the hypothesis that high-frequency oscillatory ventilation reduces the risk of lung damage in preterm infants.

Original languageEnglish
Pages (from-to)121-126
Number of pages6
JournalThe Journal of pediatrics
Volume115
Issue number1
DOIs
StatePublished - Jan 1 1989

Fingerprint

Premature Infants
High-Frequency Ventilation
Lung
Artificial Respiration
Functional Residual Capacity
Ventilation
Barotrauma
Lung Compliance
Pressure
Enteral Nutrition
Birth Weight
Gestational Age
Reference Values
Parturition
Oxygen
Weights and Measures
Water
Incidence
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Pulmonary function in preterm infants whose lungs were ventilated conventionally or by high-frequency oscillation. / Gerhardt, Tilo; Reifenberg, Linda; Goldberg, Ronald N.; Bancalari, Eduardo.

In: The Journal of pediatrics, Vol. 115, No. 1, 01.01.1989, p. 121-126.

Research output: Contribution to journalArticle

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