Abstract
Protocols of donor bone marrow infusion for tolerance induction are receiving increasing attention in clinical trials of organ allotransplantation. We report pulmonary embolism with bone fragments following vertebral body marrow infusion in a recipient of a liver and intestinal transplant. Even though pulmonary embolism with bony microfragments has been widely described following bone marrow transplantation, the use of single, high-dose donor bone marrow infusion and/or multiple infusions currently under clinical investigation for induction of donor specific unresponsiveness, may warrant the implementation of additional steps in the vertebral body marrow processing technique to decrease or eliminate the component of bony microfragments in the final preparation.
| Original language | English |
|---|---|
| Pages (from-to) | 513-516 |
| Number of pages | 4 |
| Journal | Cell Transplantation |
| Volume | 5 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 1 1996 |
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Keywords
- Bone fragments
- Bone marrow
- Cures pulmonary embolism
- Tolerance
- Vertebral body
ASJC Scopus subject areas
- Cell Biology
- Transplantation
Cite this
Pulmonary embolism with bone fragments following vertebral body marrow infusion for tolerance induction. / Fernandez, Luis A.; Romaguera, Rita; Viciana, Ana L.; Ruiz, Phillip; Tzakis, Andreas G.; Ricordi, Camillo.
In: Cell Transplantation, Vol. 5, No. 4, 01.07.1996, p. 513-516.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pulmonary embolism with bone fragments following vertebral body marrow infusion for tolerance induction
AU - Fernandez, Luis A.
AU - Romaguera, Rita
AU - Viciana, Ana L.
AU - Ruiz, Phillip
AU - Tzakis, Andreas G.
AU - Ricordi, Camillo
PY - 1996/7/1
Y1 - 1996/7/1
N2 - Protocols of donor bone marrow infusion for tolerance induction are receiving increasing attention in clinical trials of organ allotransplantation. We report pulmonary embolism with bone fragments following vertebral body marrow infusion in a recipient of a liver and intestinal transplant. Even though pulmonary embolism with bony microfragments has been widely described following bone marrow transplantation, the use of single, high-dose donor bone marrow infusion and/or multiple infusions currently under clinical investigation for induction of donor specific unresponsiveness, may warrant the implementation of additional steps in the vertebral body marrow processing technique to decrease or eliminate the component of bony microfragments in the final preparation.
AB - Protocols of donor bone marrow infusion for tolerance induction are receiving increasing attention in clinical trials of organ allotransplantation. We report pulmonary embolism with bone fragments following vertebral body marrow infusion in a recipient of a liver and intestinal transplant. Even though pulmonary embolism with bony microfragments has been widely described following bone marrow transplantation, the use of single, high-dose donor bone marrow infusion and/or multiple infusions currently under clinical investigation for induction of donor specific unresponsiveness, may warrant the implementation of additional steps in the vertebral body marrow processing technique to decrease or eliminate the component of bony microfragments in the final preparation.
KW - Bone fragments
KW - Bone marrow
KW - Cures pulmonary embolism
KW - Tolerance
KW - Vertebral body
UR - http://www.scopus.com/inward/record.url?scp=0029986219&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029986219&partnerID=8YFLogxK
U2 - 10.1016/0963-6897(96)00026-7
DO - 10.1016/0963-6897(96)00026-7
M3 - Article
C2 - 8800520
AN - SCOPUS:0029986219
VL - 5
SP - 513
EP - 516
JO - Cell Transplantation
JF - Cell Transplantation
SN - 0963-6897
IS - 4
ER -