Pulmonary embolism with bone fragments following vertebral body marrow infusion for tolerance induction

Luis A. Fernandez; Rita Romaguera; Ana L. Viciana; Phillip Ruiz; Andreas G. Tzakis; Camillo Ricordi

doi:10.1016/0963-6897(96)00026-7

Pulmonary embolism with bone fragments following vertebral body marrow infusion for tolerance induction

Luis A. Fernandez, Rita Romaguera, Ana L. Viciana, Phillip Ruiz, Andreas G. Tzakis, Camillo Ricordi

Surgery

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3 Scopus citations

Abstract

Protocols of donor bone marrow infusion for tolerance induction are receiving increasing attention in clinical trials of organ allotransplantation. We report pulmonary embolism with bone fragments following vertebral body marrow infusion in a recipient of a liver and intestinal transplant. Even though pulmonary embolism with bony microfragments has been widely described following bone marrow transplantation, the use of single, high-dose donor bone marrow infusion and/or multiple infusions currently under clinical investigation for induction of donor specific unresponsiveness, may warrant the implementation of additional steps in the vertebral body marrow processing technique to decrease or eliminate the component of bony microfragments in the final preparation.

Original language	English (US)
Pages (from-to)	513-516
Number of pages	4
Journal	Cell Transplantation
Volume	5
Issue number	4
DOIs	https://doi.org/10.1016/0963-6897(96)00026-7
State	Published - Jan 1 1996

Keywords

Bone fragments
Bone marrow
Cures pulmonary embolism
Tolerance
Vertebral body

ASJC Scopus subject areas

Cell Biology
Transplantation

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10.1016/0963-6897(96)00026-7

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abstract = "Protocols of donor bone marrow infusion for tolerance induction are receiving increasing attention in clinical trials of organ allotransplantation. We report pulmonary embolism with bone fragments following vertebral body marrow infusion in a recipient of a liver and intestinal transplant. Even though pulmonary embolism with bony microfragments has been widely described following bone marrow transplantation, the use of single, high-dose donor bone marrow infusion and/or multiple infusions currently under clinical investigation for induction of donor specific unresponsiveness, may warrant the implementation of additional steps in the vertebral body marrow processing technique to decrease or eliminate the component of bony microfragments in the final preparation.",

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AU - Fernandez, Luis A.

AU - Romaguera, Rita

AU - Viciana, Ana L.

AU - Ruiz, Phillip

AU - Tzakis, Andreas G.

AU - Ricordi, Camillo

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N2 - Protocols of donor bone marrow infusion for tolerance induction are receiving increasing attention in clinical trials of organ allotransplantation. We report pulmonary embolism with bone fragments following vertebral body marrow infusion in a recipient of a liver and intestinal transplant. Even though pulmonary embolism with bony microfragments has been widely described following bone marrow transplantation, the use of single, high-dose donor bone marrow infusion and/or multiple infusions currently under clinical investigation for induction of donor specific unresponsiveness, may warrant the implementation of additional steps in the vertebral body marrow processing technique to decrease or eliminate the component of bony microfragments in the final preparation.

AB - Protocols of donor bone marrow infusion for tolerance induction are receiving increasing attention in clinical trials of organ allotransplantation. We report pulmonary embolism with bone fragments following vertebral body marrow infusion in a recipient of a liver and intestinal transplant. Even though pulmonary embolism with bony microfragments has been widely described following bone marrow transplantation, the use of single, high-dose donor bone marrow infusion and/or multiple infusions currently under clinical investigation for induction of donor specific unresponsiveness, may warrant the implementation of additional steps in the vertebral body marrow processing technique to decrease or eliminate the component of bony microfragments in the final preparation.

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KW - Cures pulmonary embolism

KW - Tolerance

KW - Vertebral body

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Pulmonary embolism with bone fragments following vertebral body marrow infusion for tolerance induction

Abstract

Keywords

ASJC Scopus subject areas

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