Pulmonary embolism with bone fragments following vertebral body marrow infusion for tolerance induction

Luis A. Fernandez, Rita Romaguera, Ana L. Viciana, Phillip Ruiz, Andreas G. Tzakis, Camillo Ricordi

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Protocols of donor bone marrow infusion for tolerance induction are receiving increasing attention in clinical trials of organ allotransplantation. We report pulmonary embolism with bone fragments following vertebral body marrow infusion in a recipient of a liver and intestinal transplant. Even though pulmonary embolism with bony microfragments has been widely described following bone marrow transplantation, the use of single, high-dose donor bone marrow infusion and/or multiple infusions currently under clinical investigation for induction of donor specific unresponsiveness, may warrant the implementation of additional steps in the vertebral body marrow processing technique to decrease or eliminate the component of bony microfragments in the final preparation.

Original languageEnglish (US)
Pages (from-to)513-516
Number of pages4
JournalCell Transplantation
Volume5
Issue number4
DOIs
StatePublished - Jan 1 1996

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Keywords

  • Bone fragments
  • Bone marrow
  • Cures pulmonary embolism
  • Tolerance
  • Vertebral body

ASJC Scopus subject areas

  • Cell Biology
  • Transplantation

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