Pulmonary embolism in a patient with eosinophilic esophagitis: Causal or coincidental?

Patricia D. Jones, Stephan Moll, Evan S. Dellon

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Eosinophilic esophagitis is a chronic immune-mediated disease characterized by infiltration of the esophageal mucosa with eosinophils and concomitant esophageal dysfunction. Though there are well-described associations between certain chronic inflammatory conditions and venous thromboembolism, there have been no reports of venous thromboembolism occurring in eosinophilic esophagitis. We report the case of a 33-year-old man with severe eosinophilic esophagitis resulting in recurrent esophageal strictures who was unresponsive to oral viscous budesonide therapy, and who developed an isolated pulmonary embolism in the absence of risk factors for venous thromboembolism. We then discuss potential mechanisms for venous thromboembolism in eosinophilic esophagitis, such as inflammation-mediated hypercoagulability, hypereosinophilia, and immunoglobulin E-mediated platelet activation.

Original languageEnglish (US)
Pages (from-to)82-88
Number of pages7
JournalCase Reports in Gastroenterology
Volume7
Issue number1
DOIs
StatePublished - Jan 2013
Externally publishedYes

Keywords

  • Deep vein thrombosis
  • Eosinophilic esophagitis
  • Inflammation
  • Pulmonary embolism
  • Venous thromboembolism

ASJC Scopus subject areas

  • Gastroenterology

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