Pulmonary bone marrow embolism in sickle cell disease

Paula Eckardt, Luis E. Raez, Alvaro Restrepo, J. Donald Temple

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


We report an unusual lethal complication of sickle cell anemia. The patient was admitted with a diagnosis of acute chest syndrome and died shortly after that of respiratory failure. Autopsy revealed numerous deposits of bone marrow hematopoietic tissue occluding the microvascular circulation of the lung. Many causes of acute chest syndrome in sickle cell anemia have been identified, including bone marrow infarction leading to embolism of bone marrow fat. However, the release of bone marrow hematopoietic tissue leading to pulmonary vascular occlusion is not generally recognized premortem by treating physicians.

Original languageEnglish (US)
Pages (from-to)245-247
Number of pages3
JournalSouthern medical journal
Issue number2
StatePublished - Feb 1999
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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