Pulmonary arterial blood volume and tissue volume in man and dog

M. A. Sackner, N. Atkins, J. Goldberg, N. Segel, S. Zarzecki, Adam Wanner

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

After the injection of an ethyl ether alcohol solution above the pulmonic valve, the pulmonary arterial circulation time was determined in conscious man by an established body plethysmographic technique and in anesthetized man by a newly developed pneumotachographic method. In the anesthetized dog, estimates of pulmonary arterial circulation time determined by this new method were compared with those simultaneously determined by the plethysmographic method; agreement was good. The usefulness of applying corrective factors for the right to left intrapulmonary shunt and the uptake of ether gas from the alveoli into the blood while the ether gas is being evolved from the initial injection was evaluated from the dog experiments. In five humans with normal pulmonary arterial pressures, pulmonary arterial blood volume estimated by these methods was 172 ± 22 (SD) ml. Estimates of pulmonary tissue volume in both dogs and man were much larger than previously reported values determined from the tritiated water space of the lungs but more in keeping with previously published estimates of the total water content of the lungs determined at postmortem examination.

Original languageEnglish
Pages (from-to)761-769
Number of pages9
JournalCirculation Research
Volume34
Issue number6
StatePublished - Dec 1 1974
Externally publishedYes

Fingerprint

Blood Volume
Dogs
Lung
Ether
Pulmonary Circulation
Gases
Injections
Water
Autopsy
Arterial Pressure
Alcohols

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Sackner, M. A., Atkins, N., Goldberg, J., Segel, N., Zarzecki, S., & Wanner, A. (1974). Pulmonary arterial blood volume and tissue volume in man and dog. Circulation Research, 34(6), 761-769.

Pulmonary arterial blood volume and tissue volume in man and dog. / Sackner, M. A.; Atkins, N.; Goldberg, J.; Segel, N.; Zarzecki, S.; Wanner, Adam.

In: Circulation Research, Vol. 34, No. 6, 01.12.1974, p. 761-769.

Research output: Contribution to journalArticle

Sackner, MA, Atkins, N, Goldberg, J, Segel, N, Zarzecki, S & Wanner, A 1974, 'Pulmonary arterial blood volume and tissue volume in man and dog', Circulation Research, vol. 34, no. 6, pp. 761-769.
Sackner MA, Atkins N, Goldberg J, Segel N, Zarzecki S, Wanner A. Pulmonary arterial blood volume and tissue volume in man and dog. Circulation Research. 1974 Dec 1;34(6):761-769.
Sackner, M. A. ; Atkins, N. ; Goldberg, J. ; Segel, N. ; Zarzecki, S. ; Wanner, Adam. / Pulmonary arterial blood volume and tissue volume in man and dog. In: Circulation Research. 1974 ; Vol. 34, No. 6. pp. 761-769.
@article{354ffd1dd3c147beb14fb4c3ab978bfb,
title = "Pulmonary arterial blood volume and tissue volume in man and dog",
abstract = "After the injection of an ethyl ether alcohol solution above the pulmonic valve, the pulmonary arterial circulation time was determined in conscious man by an established body plethysmographic technique and in anesthetized man by a newly developed pneumotachographic method. In the anesthetized dog, estimates of pulmonary arterial circulation time determined by this new method were compared with those simultaneously determined by the plethysmographic method; agreement was good. The usefulness of applying corrective factors for the right to left intrapulmonary shunt and the uptake of ether gas from the alveoli into the blood while the ether gas is being evolved from the initial injection was evaluated from the dog experiments. In five humans with normal pulmonary arterial pressures, pulmonary arterial blood volume estimated by these methods was 172 ± 22 (SD) ml. Estimates of pulmonary tissue volume in both dogs and man were much larger than previously reported values determined from the tritiated water space of the lungs but more in keeping with previously published estimates of the total water content of the lungs determined at postmortem examination.",
author = "Sackner, {M. A.} and N. Atkins and J. Goldberg and N. Segel and S. Zarzecki and Adam Wanner",
year = "1974",
month = "12",
day = "1",
language = "English",
volume = "34",
pages = "761--769",
journal = "Circulation Research",
issn = "0009-7330",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Pulmonary arterial blood volume and tissue volume in man and dog

AU - Sackner, M. A.

AU - Atkins, N.

AU - Goldberg, J.

AU - Segel, N.

AU - Zarzecki, S.

AU - Wanner, Adam

PY - 1974/12/1

Y1 - 1974/12/1

N2 - After the injection of an ethyl ether alcohol solution above the pulmonic valve, the pulmonary arterial circulation time was determined in conscious man by an established body plethysmographic technique and in anesthetized man by a newly developed pneumotachographic method. In the anesthetized dog, estimates of pulmonary arterial circulation time determined by this new method were compared with those simultaneously determined by the plethysmographic method; agreement was good. The usefulness of applying corrective factors for the right to left intrapulmonary shunt and the uptake of ether gas from the alveoli into the blood while the ether gas is being evolved from the initial injection was evaluated from the dog experiments. In five humans with normal pulmonary arterial pressures, pulmonary arterial blood volume estimated by these methods was 172 ± 22 (SD) ml. Estimates of pulmonary tissue volume in both dogs and man were much larger than previously reported values determined from the tritiated water space of the lungs but more in keeping with previously published estimates of the total water content of the lungs determined at postmortem examination.

AB - After the injection of an ethyl ether alcohol solution above the pulmonic valve, the pulmonary arterial circulation time was determined in conscious man by an established body plethysmographic technique and in anesthetized man by a newly developed pneumotachographic method. In the anesthetized dog, estimates of pulmonary arterial circulation time determined by this new method were compared with those simultaneously determined by the plethysmographic method; agreement was good. The usefulness of applying corrective factors for the right to left intrapulmonary shunt and the uptake of ether gas from the alveoli into the blood while the ether gas is being evolved from the initial injection was evaluated from the dog experiments. In five humans with normal pulmonary arterial pressures, pulmonary arterial blood volume estimated by these methods was 172 ± 22 (SD) ml. Estimates of pulmonary tissue volume in both dogs and man were much larger than previously reported values determined from the tritiated water space of the lungs but more in keeping with previously published estimates of the total water content of the lungs determined at postmortem examination.

UR - http://www.scopus.com/inward/record.url?scp=0016158778&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016158778&partnerID=8YFLogxK

M3 - Article

VL - 34

SP - 761

EP - 769

JO - Circulation Research

JF - Circulation Research

SN - 0009-7330

IS - 6

ER -