PTPRC (CD45) is not associated with the development of multiple sclerosis in U.S. patients

Lisa F. Barcellos, Stacy Caillier, Leonard Dragone, Melissa Elder, Eric Vittinghoff, Patricia Bucher, Robin R. Lincoln, Margaret Pericak-Vance, Jonathan L. Haines, Arthur Weiss, Stephen L. Hauser, Jorge R. Oksenberg

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

A C→G nucleotide transition in exon 4 of PTPRC (encoding protein-tyrosine phosphatase receptor-type C, also known as CD45) was recently reported to be genetically associated with the development of multiple sclerosis (MS). We performed an extensive evaluation of this polymorphism using large family-based and case-control comparisons. Overall, we observed no evidence of genetic association between the PTPRC polymorphism and MS susceptibility or disease course.

Original languageEnglish (US)
Pages (from-to)23-24
Number of pages2
JournalNature genetics
Volume29
Issue number1
DOIs
StatePublished - Sep 12 2001
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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    Barcellos, L. F., Caillier, S., Dragone, L., Elder, M., Vittinghoff, E., Bucher, P., Lincoln, R. R., Pericak-Vance, M., Haines, J. L., Weiss, A., Hauser, S. L., & Oksenberg, J. R. (2001). PTPRC (CD45) is not associated with the development of multiple sclerosis in U.S. patients. Nature genetics, 29(1), 23-24. https://doi.org/10.1038/ng722