PTEN/mTOR and axon regeneration

Kevin K. Park, Kai Liu, Yang Hu, Jennifer L. Kanter, Zhigang He

Research output: Contribution to journalReview article

170 Scopus citations

Abstract

How axon regeneration is controlled in both PNS and CNS remains elusive. Mechanistic studies of axon growth during development and axon regeneration after injury reveal the PTEN dependent molecular mechanism as a commonality. This pathway could impact the processes occurring in the neuronal soma, such as mTOR-regulated protein translation, and in the axons, such as cytoskeleton assembly. In this review, we will discuss the current understanding of the involvement of these processes in the regulation of axon growth and the potential implication in promoting axon regeneration after injury.

Original languageEnglish (US)
Pages (from-to)45-50
Number of pages6
JournalExperimental Neurology
Volume223
Issue number1
DOIs
StatePublished - May 1 2010
Externally publishedYes

Keywords

  • Axon
  • CNS
  • MTOR
  • PNS
  • Pten
  • Regeneration

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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