PTB or not to be

Promiscuous, tolerant and bizarro domains come of age

Amjad Farooq, Ming Ming Zhou

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

PTB domains are protein modules that usually interact with the cytoplasmic tail of a wide variety of growth factor receptors. In so doing, they mediate the transduction of extracellular information to specific downstream targets within the cell that ultimately determine the fate of a number of important biological processes such as cell growth and differentiation, cell cycle regulation and apoptosis. Recent structural and functional studies of PTB domains from a variety of cellular proteins have begun to shed light on the molecular mechanisms of action of these important protein modules. In the present review, we provide an account of such studies and suggest that PTB domains can be subdivided into three distinct categories on the basis of their topological differences. We also discuss the various mechanisms employed by the PTB domains in recognition of a diverse set of ligands without a consensus sequence. Finally, we discuss the role of molecular plasticity as a possible determinant of functional versatility of PTB domains.

Original languageEnglish
Pages (from-to)547-556
Number of pages10
JournalIUBMB Life
Volume56
Issue number9
DOIs
StatePublished - Sep 1 2004

Fingerprint

Polypyrimidine Tract-Binding Protein
Biological Phenomena
Growth Factor Receptors
Consensus Sequence
Cell Differentiation
Cell Cycle
Proteins
Cell growth
Apoptosis
Ligands
Plasticity
Growth
Cells

Keywords

  • Cancer
  • Conformational change
  • Growth factor receptors
  • Ligand binding
  • Promiscuity
  • PTB sub-family
  • Signal transduction

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

PTB or not to be : Promiscuous, tolerant and bizarro domains come of age. / Farooq, Amjad; Zhou, Ming Ming.

In: IUBMB Life, Vol. 56, No. 9, 01.09.2004, p. 547-556.

Research output: Contribution to journalArticle

Farooq, Amjad ; Zhou, Ming Ming. / PTB or not to be : Promiscuous, tolerant and bizarro domains come of age. In: IUBMB Life. 2004 ; Vol. 56, No. 9. pp. 547-556.
@article{8ab00c36615a44bf914c42556f4003a7,
title = "PTB or not to be: Promiscuous, tolerant and bizarro domains come of age",
abstract = "PTB domains are protein modules that usually interact with the cytoplasmic tail of a wide variety of growth factor receptors. In so doing, they mediate the transduction of extracellular information to specific downstream targets within the cell that ultimately determine the fate of a number of important biological processes such as cell growth and differentiation, cell cycle regulation and apoptosis. Recent structural and functional studies of PTB domains from a variety of cellular proteins have begun to shed light on the molecular mechanisms of action of these important protein modules. In the present review, we provide an account of such studies and suggest that PTB domains can be subdivided into three distinct categories on the basis of their topological differences. We also discuss the various mechanisms employed by the PTB domains in recognition of a diverse set of ligands without a consensus sequence. Finally, we discuss the role of molecular plasticity as a possible determinant of functional versatility of PTB domains.",
keywords = "Cancer, Conformational change, Growth factor receptors, Ligand binding, Promiscuity, PTB sub-family, Signal transduction",
author = "Amjad Farooq and Zhou, {Ming Ming}",
year = "2004",
month = "9",
day = "1",
doi = "10.1080/15216540400013895",
language = "English",
volume = "56",
pages = "547--556",
journal = "IUBMB Life",
issn = "1521-6543",
publisher = "Wiley-Blackwell",
number = "9",

}

TY - JOUR

T1 - PTB or not to be

T2 - Promiscuous, tolerant and bizarro domains come of age

AU - Farooq, Amjad

AU - Zhou, Ming Ming

PY - 2004/9/1

Y1 - 2004/9/1

N2 - PTB domains are protein modules that usually interact with the cytoplasmic tail of a wide variety of growth factor receptors. In so doing, they mediate the transduction of extracellular information to specific downstream targets within the cell that ultimately determine the fate of a number of important biological processes such as cell growth and differentiation, cell cycle regulation and apoptosis. Recent structural and functional studies of PTB domains from a variety of cellular proteins have begun to shed light on the molecular mechanisms of action of these important protein modules. In the present review, we provide an account of such studies and suggest that PTB domains can be subdivided into three distinct categories on the basis of their topological differences. We also discuss the various mechanisms employed by the PTB domains in recognition of a diverse set of ligands without a consensus sequence. Finally, we discuss the role of molecular plasticity as a possible determinant of functional versatility of PTB domains.

AB - PTB domains are protein modules that usually interact with the cytoplasmic tail of a wide variety of growth factor receptors. In so doing, they mediate the transduction of extracellular information to specific downstream targets within the cell that ultimately determine the fate of a number of important biological processes such as cell growth and differentiation, cell cycle regulation and apoptosis. Recent structural and functional studies of PTB domains from a variety of cellular proteins have begun to shed light on the molecular mechanisms of action of these important protein modules. In the present review, we provide an account of such studies and suggest that PTB domains can be subdivided into three distinct categories on the basis of their topological differences. We also discuss the various mechanisms employed by the PTB domains in recognition of a diverse set of ligands without a consensus sequence. Finally, we discuss the role of molecular plasticity as a possible determinant of functional versatility of PTB domains.

KW - Cancer

KW - Conformational change

KW - Growth factor receptors

KW - Ligand binding

KW - Promiscuity

KW - PTB sub-family

KW - Signal transduction

UR - http://www.scopus.com/inward/record.url?scp=10344234238&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10344234238&partnerID=8YFLogxK

U2 - 10.1080/15216540400013895

DO - 10.1080/15216540400013895

M3 - Article

VL - 56

SP - 547

EP - 556

JO - IUBMB Life

JF - IUBMB Life

SN - 1521-6543

IS - 9

ER -