We attempted to determine the relationship between psychiatric symptoms and psychotropic drug use in persons with Alzheimer's disease based on a multicenter patient registry of 671 community-living persons diagnosed with the disease by published criteria. Logistic regression was performed to determine which symptoms were associated psychotropic use after controlling for age, sex, and Mini-Mental Status Examination (MMSE) score. At least one psychotropic drug was reported by 31% of patients, and 66% had at least one psychiatric symptom. Antipsychotics were associated with a lower MMSE score (odds ratio=0.92, 95% confidence interval 0.88-0.97), emotional lability (OR=4.52, 95% CI 1.69-11.94), and hallucinations (OR=6.54, 95% CI 2.99- 14.26). Antidepressants were associated with depressive symptoms (OR=5.8, 95% CI 2.61-13.46), and benzodiazepines with a lower MMSE score (OR=0.93, 95% CI 0.90-0.97). Community-living persons with Alzheimer's disease are frequently prescribed psychotropic drugs; however, more than 50% of patients with a psychiatric symptom did not report taking one of these agents. This suggests that alternative therapies and no treatment are also prevalent.
|Original language||English (US)|
|Number of pages||7|
|Journal||Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy|
|State||Published - Jan 1 1995|
ASJC Scopus subject areas
- Pharmacology (medical)