Abstract
Pruritus and psyche are intricately and reciprocally related, with psychophysiological evidence and psychopathological explanations helping us to understand their complex association. Their interaction may be conceptualized and classified into 3 groups: pruritic diseases with psychiatric sequelae, pruritic diseases aggravated by psychosocial factors, and psychiatric disorders causing pruritus. Management of chronic pruritus is directed at treating the underlying causes and adopting a multidisciplinary approach to address the dermatologic, somatosensory, cognitive, and emotional aspects. Pharmcotherapeutic agents that are useful for chronic pruritus with comorbid depression and/or anxiety comprise selective serotonin reuptake inhibitors, mirtazapine, tricyclic antidepressants (amitriptyline and doxepin), and anticonvulsants (gabapentin, pregabalin); the role of neurokinin receptor-1 antagonists awaits verification. Antipsychotics are required for treating itch and formication associated with schizophrenia and delusion of parasitosis (including Morgellons disease).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 31-40 |
| Number of pages | 10 |
| Journal | Clinics in Dermatology |
| Volume | 31 |
| Issue number | 1 |
| DOIs |
|
| State | Published - Jan 1 2013 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Dermatology
Cite this
Psychosomatic factors in pruritus. / Tey, Hong Liang; Wallengren, Joanna; Yosipovitch, Gil.
In: Clinics in Dermatology, Vol. 31, No. 1, 01.01.2013, p. 31-40.Research output: Contribution to journal › Comment/debate
}
TY - JOUR
T1 - Psychosomatic factors in pruritus
AU - Tey, Hong Liang
AU - Wallengren, Joanna
AU - Yosipovitch, Gil
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Pruritus and psyche are intricately and reciprocally related, with psychophysiological evidence and psychopathological explanations helping us to understand their complex association. Their interaction may be conceptualized and classified into 3 groups: pruritic diseases with psychiatric sequelae, pruritic diseases aggravated by psychosocial factors, and psychiatric disorders causing pruritus. Management of chronic pruritus is directed at treating the underlying causes and adopting a multidisciplinary approach to address the dermatologic, somatosensory, cognitive, and emotional aspects. Pharmcotherapeutic agents that are useful for chronic pruritus with comorbid depression and/or anxiety comprise selective serotonin reuptake inhibitors, mirtazapine, tricyclic antidepressants (amitriptyline and doxepin), and anticonvulsants (gabapentin, pregabalin); the role of neurokinin receptor-1 antagonists awaits verification. Antipsychotics are required for treating itch and formication associated with schizophrenia and delusion of parasitosis (including Morgellons disease).
AB - Pruritus and psyche are intricately and reciprocally related, with psychophysiological evidence and psychopathological explanations helping us to understand their complex association. Their interaction may be conceptualized and classified into 3 groups: pruritic diseases with psychiatric sequelae, pruritic diseases aggravated by psychosocial factors, and psychiatric disorders causing pruritus. Management of chronic pruritus is directed at treating the underlying causes and adopting a multidisciplinary approach to address the dermatologic, somatosensory, cognitive, and emotional aspects. Pharmcotherapeutic agents that are useful for chronic pruritus with comorbid depression and/or anxiety comprise selective serotonin reuptake inhibitors, mirtazapine, tricyclic antidepressants (amitriptyline and doxepin), and anticonvulsants (gabapentin, pregabalin); the role of neurokinin receptor-1 antagonists awaits verification. Antipsychotics are required for treating itch and formication associated with schizophrenia and delusion of parasitosis (including Morgellons disease).
UR - http://www.scopus.com/inward/record.url?scp=84871070281&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84871070281&partnerID=8YFLogxK
U2 - 10.1016/j.clindermatol.2011.11.004
DO - 10.1016/j.clindermatol.2011.11.004
M3 - Comment/debate
C2 - 23245971
AN - SCOPUS:84871070281
VL - 31
SP - 31
EP - 40
JO - Clinics in Dermatology
JF - Clinics in Dermatology
SN - 0738-081X
IS - 1
ER -