Psychosocial Syndemics are Additively Associated with Worse ART Adherence in HIV-Infected Individuals

Aaron J. Blashill, C. Andres Bedoya, Kenneth H. Mayer, Conall O’Cleirigh, Megan M. Pinkston, Jocelyn E. Remmert, Matthew J. Mimiaga, Steven Safren

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Adherence to antiretroviral therapy (ART) among HIV-infected individuals is necessary to both individual and public health, and psychosocial problems have independently been associated with poor adherence. To date, studies have not systematically examined the effect of multiple, co-occurring psychosocial problems (i.e., “syndemics”) on ART adherence. Participants included 333 HIV-infected individuals who completed a comprehensive baseline evaluation, as part of a clinical trial to evaluate an intervention to treat depression and optimize medication adherence. Participants completed self-report questionnaires, and trained clinicians completed semi-structured diagnostic interviews. ART non-adherence was objectively measured via an electronic pill cap (i.e., MEMS). As individuals reported a greater number of syndemic indicators, their odds of non-adherence increased. Co-occurring psychosocial problems have an additive effect on the risk for poor ART adherence. Future behavioral medicine interventions are needed that address these problems comprehensively, and/or the core mechanisms that they share.

Original languageEnglish (US)
Pages (from-to)981-986
Number of pages6
JournalAIDS and Behavior
Volume19
Issue number6
DOIs
StatePublished - Oct 21 2015
Externally publishedYes

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HIV
Micro-Electrical-Mechanical Systems
Behavioral Medicine
Medication Adherence
Therapeutics
Self Report
Public Health
Clinical Trials
Interviews
Depression
Surveys and Questionnaires

Keywords

  • Adherence
  • Antiretroviral therapy
  • ART
  • Comorbidity
  • HIV
  • Syndemics

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases
  • Social Psychology

Cite this

Blashill, A. J., Bedoya, C. A., Mayer, K. H., O’Cleirigh, C., Pinkston, M. M., Remmert, J. E., ... Safren, S. (2015). Psychosocial Syndemics are Additively Associated with Worse ART Adherence in HIV-Infected Individuals. AIDS and Behavior, 19(6), 981-986. https://doi.org/10.1007/s10461-014-0925-6

Psychosocial Syndemics are Additively Associated with Worse ART Adherence in HIV-Infected Individuals. / Blashill, Aaron J.; Bedoya, C. Andres; Mayer, Kenneth H.; O’Cleirigh, Conall; Pinkston, Megan M.; Remmert, Jocelyn E.; Mimiaga, Matthew J.; Safren, Steven.

In: AIDS and Behavior, Vol. 19, No. 6, 21.10.2015, p. 981-986.

Research output: Contribution to journalArticle

Blashill, AJ, Bedoya, CA, Mayer, KH, O’Cleirigh, C, Pinkston, MM, Remmert, JE, Mimiaga, MJ & Safren, S 2015, 'Psychosocial Syndemics are Additively Associated with Worse ART Adherence in HIV-Infected Individuals', AIDS and Behavior, vol. 19, no. 6, pp. 981-986. https://doi.org/10.1007/s10461-014-0925-6
Blashill AJ, Bedoya CA, Mayer KH, O’Cleirigh C, Pinkston MM, Remmert JE et al. Psychosocial Syndemics are Additively Associated with Worse ART Adherence in HIV-Infected Individuals. AIDS and Behavior. 2015 Oct 21;19(6):981-986. https://doi.org/10.1007/s10461-014-0925-6
Blashill, Aaron J. ; Bedoya, C. Andres ; Mayer, Kenneth H. ; O’Cleirigh, Conall ; Pinkston, Megan M. ; Remmert, Jocelyn E. ; Mimiaga, Matthew J. ; Safren, Steven. / Psychosocial Syndemics are Additively Associated with Worse ART Adherence in HIV-Infected Individuals. In: AIDS and Behavior. 2015 ; Vol. 19, No. 6. pp. 981-986.
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