Psychosis of epilepsy: A multifaceted neuropsychiatric disorder

Andres M Kanner, Ana Maria Rivas-Grajales

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Psychosis of epilepsy (POE) is a term applied to a group of psychotic disorders with a distinct phenomenology in which potential etiopathogenic mechanisms are believed to be closely related to a seizure disorder. POE can present as interictal psychotic episodes, which may often differ semiologically from primary schizophrenic disorder. They may present as ictal or postictal psychotic episodes and may be the expression of an iatrogenic process to pharmacologic and/or surgical interventions.Epilepsy and POE have a complex and bidirectional relation, as not only are patients with epilepsy at greater risk of developing a psychotic disorder, but patients with a primary psychotic disorder are also at greater risk of developing epilepsy. The prevalence of POE is more than 7 times higher than the frequency of primary schizophreniform disorders in the general population. While POE has been associated with focal epilepsy of temporal and frontal lobe origin, its etiology and pathophysiology of POE have yet to be established.The treatment of all forms of POE, with the exception of ictal psychotic episodes, requires the use of antipsychotic drugs, preferably the atypical antipsychotic agents with a very low or negligible potential to lower the seizure threshold (eg, risperidone, apiprazole), starting at a low dose with stepwise increments.

Original languageEnglish (US)
Pages (from-to)247-257
Number of pages11
JournalCNS Spectrums
Volume21
Issue number3
DOIs
StatePublished - Jun 1 2016

Fingerprint

Psychotic Disorders
Epilepsy
Antipsychotic Agents
Stroke
Risperidone
Partial Epilepsy
Frontal Lobe
Temporal Lobe
Schizophrenia
Seizures

Keywords

  • Alternative psychosis
  • interictal psychosis
  • neuroleptic drugs
  • postictal psychosis
  • temporal lobe epilepsy
  • treatment-resistant epilepsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Psychosis of epilepsy : A multifaceted neuropsychiatric disorder. / Kanner, Andres M; Rivas-Grajales, Ana Maria.

In: CNS Spectrums, Vol. 21, No. 3, 01.06.2016, p. 247-257.

Research output: Contribution to journalReview article

Kanner, Andres M ; Rivas-Grajales, Ana Maria. / Psychosis of epilepsy : A multifaceted neuropsychiatric disorder. In: CNS Spectrums. 2016 ; Vol. 21, No. 3. pp. 247-257.
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