Psychophysiologic parameters of traumatic stress disorder in rats

T. Garrick, N. Morrow, Spencer Eth, D. Marciano, A. Shalev

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Nonhabituation of the acoustic startle response is used to identify rat subjects with altered alarm responses subsequent to trauma exposure. Subjects (n = 31) were exposed to 30 minutes of intermittent tail shock on 2 days followed by exposure to the apparatus on the third day. Twenty-nine percent of traumatized rats developed nonhabituation of startle over the subsequent 3 weeks of testing. No control rats developed nonhabituation of startle reactions over a similar time period. These data suggest that this system represents a more accurate representation of clinical PTSD than do other animal models.

Original languageEnglish
Pages (from-to)533-537
Number of pages5
JournalAnnals of the New York Academy of Sciences
Volume821
DOIs
StatePublished - Aug 27 1997
Externally publishedYes

Fingerprint

Traumatic Stress Disorders
Startle Reflex
Rats
Rat control
Animals
Acoustics
Post-Traumatic Stress Disorders
Information Systems
Tail
Shock
Testing
Animal Models
Wounds and Injuries
Rat

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Psychophysiologic parameters of traumatic stress disorder in rats. / Garrick, T.; Morrow, N.; Eth, Spencer; Marciano, D.; Shalev, A.

In: Annals of the New York Academy of Sciences, Vol. 821, 27.08.1997, p. 533-537.

Research output: Contribution to journalArticle

Garrick, T. ; Morrow, N. ; Eth, Spencer ; Marciano, D. ; Shalev, A. / Psychophysiologic parameters of traumatic stress disorder in rats. In: Annals of the New York Academy of Sciences. 1997 ; Vol. 821. pp. 533-537.
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