Psychophysiologic parameters of traumatic stress disorder in rats

T. Garrick, N. Morrow, S. Eth, D. Marciano, A. Shalev

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Nonhabituation of the acoustic startle response is used to identify rat subjects with altered alarm responses subsequent to trauma exposure. Subjects (n = 31) were exposed to 30 minutes of intermittent tail shock on 2 days followed by exposure to the apparatus on the third day. Twenty-nine percent of traumatized rats developed nonhabituation of startle over the subsequent 3 weeks of testing. No control rats developed nonhabituation of startle reactions over a similar time period. These data suggest that this system represents a more accurate representation of clinical PTSD than do other animal models.

Original languageEnglish (US)
Pages (from-to)533-537
Number of pages5
JournalAnnals of the New York Academy of Sciences
Volume821
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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