Psychopathology associated with Alzheimer's disease and related disorders

D. Cohen, C. Eisdorfer, P. Gorelick, G. Paveza, D. J. Luchins, S. Freels, J. W. Ashford, T. Semla, P. Levy, R. Hirschman

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Background. This study compared the occurrence of psychiatric symptoms in a large group of community-residing participants enrolled in an Alzheimer's disease patient registry who met clinical diagnostic criteria for Alzheimer's disease or multi-infarct dementia, as well as mixed Alzheimer's disease and multi-infarct dementia. Methods. Psychiatric morbidity observed from a psychiatric examination of 514 patients with Alzheimer's disease, 135 patients with multi-infarct dementia, and 86 cases with mixed dementia was analyzed using analysis of variance comparing symptoms across groups and chi- square test for differences in frequency of occurrence. Associations between pairs of symptoms were also reported. Results. The frequency of occurrence and patterns of psychiatric problems were similar in patients with Alzheimer's disease and multi-infarct dementia. Agitation was the most frequent symptom, followed by depression, apathy, and behavioral disorders. Patients with mixed dementia had significantly more psychopathology. Conclusion. This study demonstrated that significant psychopathology occurs in individuals with Alzheimer's disease or multi-infarct dementia. The high levels of symptoms in mixed dementia suggest that the two conditions have a synergistic effect on behavioral problems. The prevalence of multiple symptoms is higher than previously reported.

Original languageEnglish
JournalJournals of Gerontology
Volume48
Issue number6
StatePublished - Jan 1 1993
Externally publishedYes

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Multi-Infarct Dementia
Psychopathology
Alzheimer Disease
Psychiatry
Dementia
Apathy
Chi-Square Distribution
Registries
Analysis of Variance
Depression
Morbidity

ASJC Scopus subject areas

  • Aging

Cite this

Cohen, D., Eisdorfer, C., Gorelick, P., Paveza, G., Luchins, D. J., Freels, S., ... Hirschman, R. (1993). Psychopathology associated with Alzheimer's disease and related disorders. Journals of Gerontology, 48(6).

Psychopathology associated with Alzheimer's disease and related disorders. / Cohen, D.; Eisdorfer, C.; Gorelick, P.; Paveza, G.; Luchins, D. J.; Freels, S.; Ashford, J. W.; Semla, T.; Levy, P.; Hirschman, R.

In: Journals of Gerontology, Vol. 48, No. 6, 01.01.1993.

Research output: Contribution to journalArticle

Cohen, D, Eisdorfer, C, Gorelick, P, Paveza, G, Luchins, DJ, Freels, S, Ashford, JW, Semla, T, Levy, P & Hirschman, R 1993, 'Psychopathology associated with Alzheimer's disease and related disorders', Journals of Gerontology, vol. 48, no. 6.
Cohen D, Eisdorfer C, Gorelick P, Paveza G, Luchins DJ, Freels S et al. Psychopathology associated with Alzheimer's disease and related disorders. Journals of Gerontology. 1993 Jan 1;48(6).
Cohen, D. ; Eisdorfer, C. ; Gorelick, P. ; Paveza, G. ; Luchins, D. J. ; Freels, S. ; Ashford, J. W. ; Semla, T. ; Levy, P. ; Hirschman, R. / Psychopathology associated with Alzheimer's disease and related disorders. In: Journals of Gerontology. 1993 ; Vol. 48, No. 6.
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