Psychological distress is associated with decreased memory helper T-cell and B-cell counts in pre-AIDS HIV seropositive men and women but only in those with low viral load

Sarosh J. Motivala, Barry Hurwitz, Maria Llabre, Nancy G. Klimas, Mary Ann Fletcher, Michael H Antoni, William G. Leblanc, Neil Schneiderman

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective: Although some studies have demonstrated the association of psychological distress and diminished immune system function in HIV spectrum disease, other studies have yielded apparently conflicting findings; the lack of consideration of the role of HIV viral burden may be central to this controversy. This study examined whether HIV viral burden moderated the relationship between psychological distress and enumerative and functional immune measures in pre-AIDS HIV spectrum disease. Methods: This cross-sectional study used factor analysis to derive a composite measure of psychological distress incorporating measures of dysphoria, anxiety, and perceived stress. Multiple regression analyses used distress as the predictor, immune measures as the outcome variables, with viral load as the moderator variable, while controlling for age, medication use, and HIV symptomatology. Subjects were 148 pre-AIDS, HIV seropositive men and women (89 asymptomatic, 59 symptomatic), aged 18 to 45 years. The main outcome measures were enumerative and functional immune measures. Results: A model of psychological distress was derived using each of the proposed measures. Findings indicated that high distress was associated with decreased numbers of helper T (memory) cells and B cells, but only at low levels of viral burden after controlling for age, medication use, and HIV-related symptoms. Conclusions: These findings highlight the importance of assessing the role of HIV viral burden when examining distress-immunity relationships in HIV-infected individuals. The lack of association in those persons with high viral load suggests that, even before AIDS onset, disease-related processes are disrupting CNS and immune system communication.

Original languageEnglish
Pages (from-to)627-635
Number of pages9
JournalPsychosomatic Medicine
Volume65
Issue number4
DOIs
StatePublished - Jul 1 2003

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Helper-Inducer T-Lymphocytes
Viral Load
Acquired Immunodeficiency Syndrome
B-Lymphocytes
Cell Count
HIV
Psychology
Immune System
Outcome Assessment (Health Care)
Epidemiologic Effect Modifiers
Psychological Models
Statistical Factor Analysis
Immunity
Anxiety
Cross-Sectional Studies
Communication
Regression Analysis

Keywords

  • B lymphocytes
  • HIV-1
  • Immune system
  • Psychological stress
  • T lymphocytes
  • Viral load

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)

Cite this

Psychological distress is associated with decreased memory helper T-cell and B-cell counts in pre-AIDS HIV seropositive men and women but only in those with low viral load. / Motivala, Sarosh J.; Hurwitz, Barry; Llabre, Maria; Klimas, Nancy G.; Fletcher, Mary Ann; Antoni, Michael H; Leblanc, William G.; Schneiderman, Neil.

In: Psychosomatic Medicine, Vol. 65, No. 4, 01.07.2003, p. 627-635.

Research output: Contribution to journalArticle

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