Psycho-physiologic correlates of MSH activity in man

Abba J. Kastin, Lyle H. Miller, David Gonzalez-Barcena, William D. Hawley, Kjell Dyster-Aas, Andrew V Schally, M. Luisa Velasco de Parra, Marcos Velasco

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Abstract

The role of MSH in man is unknown. Administration of 10 mg synthetic alpha melanocyte-stimulating hormone (MSH) to 5 human subjects resulted in a significant increase in the averaged somatosensory cortical evoked response (AER). This change in the amplitude of the somatosensory evoked response was so marked that it could be seen on single trials of the EEG. The AER further increased during attention. Performance on the Benton Visual Retention Test also improved significantly after infusion of MSH. These findings demonstrate extra-pigmentary effects of MSH in man and suggest an effect upon the attentive process.

Original languageEnglish
Pages (from-to)893-896
Number of pages4
JournalPhysiology and Behavior
Volume7
Issue number6
DOIs
StatePublished - Jan 1 1971
Externally publishedYes

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Keywords

  • Attention
  • Extra-pigmentary
  • Melanocyte-stimulating hormone (MSH)
  • Somatosensory evoked response
  • Visual memory

ASJC Scopus subject areas

  • Physiology (medical)
  • Behavioral Neuroscience

Cite this

Kastin, A. J., Miller, L. H., Gonzalez-Barcena, D., Hawley, W. D., Dyster-Aas, K., Schally, A. V., Luisa Velasco de Parra, M., & Velasco, M. (1971). Psycho-physiologic correlates of MSH activity in man. Physiology and Behavior, 7(6), 893-896. https://doi.org/10.1016/0031-9384(71)90060-6