Psycho-physiologic correlates of MSH activity in man

Abba J. Kastin, Lyle H. Miller, David Gonzalez-Barcena, William D. Hawley, Kjell Dyster-Aas, Andrew V. Schally, M. Luisa Velasco de Parra, Marcos Velasco

Research output: Contribution to journalArticlepeer-review

93 Scopus citations


The role of MSH in man is unknown. Administration of 10 mg synthetic alpha melanocyte-stimulating hormone (MSH) to 5 human subjects resulted in a significant increase in the averaged somatosensory cortical evoked response (AER). This change in the amplitude of the somatosensory evoked response was so marked that it could be seen on single trials of the EEG. The AER further increased during attention. Performance on the Benton Visual Retention Test also improved significantly after infusion of MSH. These findings demonstrate extra-pigmentary effects of MSH in man and suggest an effect upon the attentive process.

Original languageEnglish (US)
Pages (from-to)893-896
Number of pages4
JournalPhysiology AND Behavior
Issue number6
StatePublished - Dec 1971
Externally publishedYes


  • Attention
  • Extra-pigmentary
  • Melanocyte-stimulating hormone (MSH)
  • Somatosensory evoked response
  • Visual memory

ASJC Scopus subject areas

  • Physiology (medical)
  • Behavioral Neuroscience


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