Psychiatric disorder does not preclude adequate continuous positive airway pressure titration

Skantha K. Manjunath, Siva T. Sarva, Jose C. Yataco, Luis C. Murillo, Jaime F. Avecillas, Amado X. Freire

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Obstructive sleep apnea (OSA) is a highly prevalent disorder associated with significant morbidity and multiple complications. A large proportion of patients with OSA also have a coexisting primary psychiatric disorder. The effect of psychiatric disorders on the ability to tolerate continuous positive airway pressure (CPAP) titration is not known. In this study, whether the presence of psychiatric disorders precludes the patients' ability to tolerate CPAP titration for OSA was investigated. A retrospective chart review on a sample of 284 patients who underwent sleep studies in a single-center, university-based Veterans Affairs hospital was performed. A total of 143 patients with OSA who underwent titration of CPAP therapy were identified. The prevalence of psychiatric disorders between patients who tolerated titration and those who did not tolerate it was compared using the χ2 test. The percentages of patients with psychiatric disorders who tolerated and did not tolerate CPAP were 33.6% and 33.3%, respectively. No statistically significant difference between the 2 groups (χ2 = 0.051 with 1 degree of freedom; P = 0.82) was found. The predominantly male patient population, exclusion of mild OSA, lack of data about the level of control of the psychiatric symptoms and the sleep technicians not being blinded to the patients' psychiatric diagnoses were some of the limitations of this study. No significant difference existed in the prevalence of psychiatric disorders between patients intolerant to CPAP titration and those who tolerated CPAP for OSA.

Original languageEnglish (US)
Pages (from-to)104-107
Number of pages4
JournalAmerican Journal of the Medical Sciences
Issue number2
StatePublished - Aug 2013


  • CPAP titration
  • Depression
  • Posttraumatic stress disorder
  • Psychiatric disorders
  • Sleep apnea
  • Tolerance

ASJC Scopus subject areas

  • Medicine(all)


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