Abstract
Objective: In this study, the effects of high stimulus rate on middle latency response (MLR) components Pa and Pb (P1 or P50) were studied using high rate clicks in normal hearing awake subjects were investigated. Methods: Five jittered click sequences at different mean rates (24.4, 39.1, 58.6, 78.1, 97.7 Hz) were presented to 10 subjects. Overlapping MLRs were deconvolved using the frequency domain continuous loop averaging deconvolution (CLAD) [Özdamar Ö., Bohórquez, J., Signal to noise ratio and frequency analysis of continuous loop averaging deconvolution (CLAD) of overlapping evoked potentials. J. Acoust. Soc. Am., 119:429-438, 2006]. In addition conventional auditory transient MLRs at 4.88 Hz were obtained using conventional averaging. Results: Pa amplitude, latency and waveshape remained fairly constant up to 78.1 Hz. Pb component, however, showed a variable waveshape with latencies covering a wide range (50-70 ms) and Nb-Pb amplitudes increasing at 39.1 and 58.6 Hz and decreasing at other rates. Conclusions: Recordings show that both Pa and Pb MLR components can be consistently recorded at all rates up to 100 Hz. Pb amplitude shows an increase at around 40 Hz showing a resonance at that frequency. Significance: The dramatic increase of the Pb component at around 40 Hz may account for the high amplitude of the 40 Hz ASSR.
| Original language | English |
|---|---|
| Pages (from-to) | 1261-1273 |
| Number of pages | 13 |
| Journal | Clinical Neurophysiology |
| Volume | 118 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 2007 |
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Keywords
- 40 Hz responses
- Auditory middle latency responses
- Auditory steady state responses
- Deconvolution of overlapping responses
- High rate effects
- P resonance
ASJC Scopus subject areas
- Clinical Neurology
- Radiology Nuclear Medicine and imaging
- Neurology
- Sensory Systems
- Physiology (medical)
Cite this
Pb(P1) resonance at 40 Hz : Effects of high stimulus rate on auditory middle latency responses (MLRs) explored using deconvolution. / Ozdamar, Ozcan; Bohorquez, Jorge; Ray, Saumitra Sinha.
In: Clinical Neurophysiology, Vol. 118, No. 6, 01.06.2007, p. 1261-1273.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pb(P1) resonance at 40 Hz
T2 - Effects of high stimulus rate on auditory middle latency responses (MLRs) explored using deconvolution
AU - Ozdamar, Ozcan
AU - Bohorquez, Jorge
AU - Ray, Saumitra Sinha
PY - 2007/6/1
Y1 - 2007/6/1
N2 - Objective: In this study, the effects of high stimulus rate on middle latency response (MLR) components Pa and Pb (P1 or P50) were studied using high rate clicks in normal hearing awake subjects were investigated. Methods: Five jittered click sequences at different mean rates (24.4, 39.1, 58.6, 78.1, 97.7 Hz) were presented to 10 subjects. Overlapping MLRs were deconvolved using the frequency domain continuous loop averaging deconvolution (CLAD) [Özdamar Ö., Bohórquez, J., Signal to noise ratio and frequency analysis of continuous loop averaging deconvolution (CLAD) of overlapping evoked potentials. J. Acoust. Soc. Am., 119:429-438, 2006]. In addition conventional auditory transient MLRs at 4.88 Hz were obtained using conventional averaging. Results: Pa amplitude, latency and waveshape remained fairly constant up to 78.1 Hz. Pb component, however, showed a variable waveshape with latencies covering a wide range (50-70 ms) and Nb-Pb amplitudes increasing at 39.1 and 58.6 Hz and decreasing at other rates. Conclusions: Recordings show that both Pa and Pb MLR components can be consistently recorded at all rates up to 100 Hz. Pb amplitude shows an increase at around 40 Hz showing a resonance at that frequency. Significance: The dramatic increase of the Pb component at around 40 Hz may account for the high amplitude of the 40 Hz ASSR.
AB - Objective: In this study, the effects of high stimulus rate on middle latency response (MLR) components Pa and Pb (P1 or P50) were studied using high rate clicks in normal hearing awake subjects were investigated. Methods: Five jittered click sequences at different mean rates (24.4, 39.1, 58.6, 78.1, 97.7 Hz) were presented to 10 subjects. Overlapping MLRs were deconvolved using the frequency domain continuous loop averaging deconvolution (CLAD) [Özdamar Ö., Bohórquez, J., Signal to noise ratio and frequency analysis of continuous loop averaging deconvolution (CLAD) of overlapping evoked potentials. J. Acoust. Soc. Am., 119:429-438, 2006]. In addition conventional auditory transient MLRs at 4.88 Hz were obtained using conventional averaging. Results: Pa amplitude, latency and waveshape remained fairly constant up to 78.1 Hz. Pb component, however, showed a variable waveshape with latencies covering a wide range (50-70 ms) and Nb-Pb amplitudes increasing at 39.1 and 58.6 Hz and decreasing at other rates. Conclusions: Recordings show that both Pa and Pb MLR components can be consistently recorded at all rates up to 100 Hz. Pb amplitude shows an increase at around 40 Hz showing a resonance at that frequency. Significance: The dramatic increase of the Pb component at around 40 Hz may account for the high amplitude of the 40 Hz ASSR.
KW - 40 Hz responses
KW - Auditory middle latency responses
KW - Auditory steady state responses
KW - Deconvolution of overlapping responses
KW - High rate effects
KW - P resonance
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UR - http://www.scopus.com/inward/citedby.url?scp=34248182025&partnerID=8YFLogxK
U2 - 10.1016/j.clinph.2007.02.016
DO - 10.1016/j.clinph.2007.02.016
M3 - Article
C2 - 17466579
AN - SCOPUS:34248182025
VL - 118
SP - 1261
EP - 1273
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 6
ER -