Abstract
Psoriasis is a chronic inflammatory disease of the skin and joints that typically follows a relapsing/remitting disease course. Whereas psoriasis is primarily a T-cell-mediated disease, intrinsic alterations in epidermal keratinocytes also play an important role. Tumor necrosis factor alpha (TNFa) has been identified as an important cytokine in the inflammatory cascade of psoriasis. The importance of TNFa is further underlined by the therapeutic efficacy of compounds that interfere with TNFa function, such as biological agents.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 11-13 |
| Number of pages | 3 |
| Journal | American Journal of Clinical Dermatology |
| Volume | 11 |
| Issue number | SUPPL. 1 |
| State | Published - 2010 |
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ASJC Scopus subject areas
- Dermatology
Cite this
Psoriasis : Targeting therapy towards the inflammatory cascade. / Miteva, Mariya.
In: American Journal of Clinical Dermatology, Vol. 11, No. SUPPL. 1, 2010, p. 11-13.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Psoriasis
T2 - Targeting therapy towards the inflammatory cascade
AU - Miteva, Mariya
PY - 2010
Y1 - 2010
N2 - Psoriasis is a chronic inflammatory disease of the skin and joints that typically follows a relapsing/remitting disease course. Whereas psoriasis is primarily a T-cell-mediated disease, intrinsic alterations in epidermal keratinocytes also play an important role. Tumor necrosis factor alpha (TNFa) has been identified as an important cytokine in the inflammatory cascade of psoriasis. The importance of TNFa is further underlined by the therapeutic efficacy of compounds that interfere with TNFa function, such as biological agents.
AB - Psoriasis is a chronic inflammatory disease of the skin and joints that typically follows a relapsing/remitting disease course. Whereas psoriasis is primarily a T-cell-mediated disease, intrinsic alterations in epidermal keratinocytes also play an important role. Tumor necrosis factor alpha (TNFa) has been identified as an important cytokine in the inflammatory cascade of psoriasis. The importance of TNFa is further underlined by the therapeutic efficacy of compounds that interfere with TNFa function, such as biological agents.
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UR - http://www.scopus.com/inward/citedby.url?scp=77954266750&partnerID=8YFLogxK
M3 - Article
C2 - 20586499
AN - SCOPUS:77954266750
VL - 11
SP - 11
EP - 13
JO - American Journal of Clinical Dermatology
JF - American Journal of Clinical Dermatology
SN - 1175-0561
IS - SUPPL. 1
ER -