Psoriasis: Targeting therapy towards the inflammatory cascade

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Psoriasis is a chronic inflammatory disease of the skin and joints that typically follows a relapsing/remitting disease course. Whereas psoriasis is primarily a T-cell-mediated disease, intrinsic alterations in epidermal keratinocytes also play an important role. Tumor necrosis factor alpha (TNFa) has been identified as an important cytokine in the inflammatory cascade of psoriasis. The importance of TNFa is further underlined by the therapeutic efficacy of compounds that interfere with TNFa function, such as biological agents.

Original languageEnglish (US)
Pages (from-to)11-13
Number of pages3
JournalAmerican Journal of Clinical Dermatology
Volume11
Issue numberSUPPL. 1
StatePublished - 2010

Fingerprint

Psoriasis
Tumor Necrosis Factor-alpha
Biological Factors
Keratinocytes
Chronic Disease
Therapeutics
Joints
Cytokines
T-Lymphocytes
Skin

ASJC Scopus subject areas

  • Dermatology

Cite this

Psoriasis : Targeting therapy towards the inflammatory cascade. / Miteva, Mariya.

In: American Journal of Clinical Dermatology, Vol. 11, No. SUPPL. 1, 2010, p. 11-13.

Research output: Contribution to journalArticle

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