Psoriasis and vascular disease-risk factors and outcomes

A systematic review of the literature

Rita V. Patel, Michael L. Shelling, Srdjan Prodanovich, Daniel G. Federman, Robert Kirsner

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Background: Psoriasis afflicts 2-3% of the world's population. Affected patients commonly have risk factors for cardiovascular disease (CVD). In addition, psoriasis is independently associated with CVD and mortality. Purpose: To determine which CVD risk factors are associated with psoriasis independent of confounders, whether psoriasis is associated with CVD independent of CVD risk factors, and whether there is increased mortality among patients with psoriasis. Data Sources: MEDLINE, Embase, and Cochrane Collaborations from inception through October 2009. We reviewed bibliographies of retrieved articles for additional references. Study Selection: Cross-sectional, cohort-based, case-control, and randomized controlled trials which involved patients with psoriasis. Data Extraction: Two investigators independently reviewed studies and resolved any discrepancies by consensus. Data Synthesis: Of the 2,303 articles identified by literature search, 90 studies met inclusion criteria for this review; 15 were cohort-based studies, 45 were case-control, and 30 were cross-sectional. Limitations: The quality of evidence was limited by study heterogeneity and lack of large scale prospective studies with long-term follow-up. Conclusions: Patients with psoriasis demonstrate a higher prevalence of cardiovascular risk factors and appear to be at increased risk for ischemic heart disease, cerebrovascular disease, and peripheral arterial disease. This increase in vascular disease may be independent of shared risk factors and may contribute to the increase in all-cause mortality. Future research should aim to more confidently distinguish between a true causal relationship or merely an association resulting from multiple shared risk factors. Physicians should screen for and aggressively treat modifiable risk factors for CVD in patients with psoriasis.

Original languageEnglish
Pages (from-to)1036-1049
Number of pages14
JournalJournal of General Internal Medicine
Volume26
Issue number9
DOIs
StatePublished - Sep 1 2011

Fingerprint

Vascular Diseases
Psoriasis
Cardiovascular Diseases
Mortality
Cerebrovascular Disorders
Information Storage and Retrieval
Peripheral Arterial Disease
Bibliography
MEDLINE
Myocardial Ischemia
Cohort Studies
Randomized Controlled Trials
Cross-Sectional Studies
Research Personnel
Prospective Studies
Physicians
Population

Keywords

  • alcohol
  • cardiovascular disease
  • cohort-based studies
  • cross-sectional studies
  • psoriasis
  • risk factors

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Psoriasis and vascular disease-risk factors and outcomes : A systematic review of the literature. / Patel, Rita V.; Shelling, Michael L.; Prodanovich, Srdjan; Federman, Daniel G.; Kirsner, Robert.

In: Journal of General Internal Medicine, Vol. 26, No. 9, 01.09.2011, p. 1036-1049.

Research output: Contribution to journalArticle

Patel, Rita V. ; Shelling, Michael L. ; Prodanovich, Srdjan ; Federman, Daniel G. ; Kirsner, Robert. / Psoriasis and vascular disease-risk factors and outcomes : A systematic review of the literature. In: Journal of General Internal Medicine. 2011 ; Vol. 26, No. 9. pp. 1036-1049.
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