Psoriasis and Vascular Disease

An Unsolved Mystery

Michael L. Shelling, Daniel G. Federman, Srdjan Prodanovich, Robert Kirsner

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Psoriasis is an immune disease most commonly recognized for its skin and joint manifestations. These produce significant physical, social, and psychological distress in affected patients and resultant reductions in their quality of life. As expected, these concerns are vital in providing symptomatic improvement and in selecting an individualized therapy. Yet, the approach in management of these patients is likely to change given the growing body of evidence linking psoriasis and vascular disease. Stemming from an anecdotally described relationship, the association between psoriasis and vascular disease has become a focus of current research to further elucidate the pathophysiology underlying and connecting these two diseases. This article includes a review of the classical cardiovascular risk factors, the atherothrombotic markers, and the environmental stressors associated with psoriasis, as well as a critical review of the observed vascular diseases, the proposed mechanism of atherosclerosis, and the benefits of treatment of psoriasis.

Original languageEnglish
Pages (from-to)360-365
Number of pages6
JournalAmerican Journal of Medicine
Volume121
Issue number5
DOIs
StatePublished - May 1 2008

Fingerprint

Vascular Diseases
Psoriasis
Skin Manifestations
Immune System Diseases
Atherosclerosis
Joints
Quality of Life
Psychology
Therapeutics
Research

Keywords

  • Atherosclerosis
  • Cardiovascular risk factors
  • Coronary artery disease
  • Myocardial infarction
  • Psoriasis
  • Systemic inflammation

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Psoriasis and Vascular Disease : An Unsolved Mystery. / Shelling, Michael L.; Federman, Daniel G.; Prodanovich, Srdjan; Kirsner, Robert.

In: American Journal of Medicine, Vol. 121, No. 5, 01.05.2008, p. 360-365.

Research output: Contribution to journalArticle

Shelling, Michael L. ; Federman, Daniel G. ; Prodanovich, Srdjan ; Kirsner, Robert. / Psoriasis and Vascular Disease : An Unsolved Mystery. In: American Journal of Medicine. 2008 ; Vol. 121, No. 5. pp. 360-365.
@article{b0d33a4fb1424fc8802c9584d029e866,
title = "Psoriasis and Vascular Disease: An Unsolved Mystery",
abstract = "Psoriasis is an immune disease most commonly recognized for its skin and joint manifestations. These produce significant physical, social, and psychological distress in affected patients and resultant reductions in their quality of life. As expected, these concerns are vital in providing symptomatic improvement and in selecting an individualized therapy. Yet, the approach in management of these patients is likely to change given the growing body of evidence linking psoriasis and vascular disease. Stemming from an anecdotally described relationship, the association between psoriasis and vascular disease has become a focus of current research to further elucidate the pathophysiology underlying and connecting these two diseases. This article includes a review of the classical cardiovascular risk factors, the atherothrombotic markers, and the environmental stressors associated with psoriasis, as well as a critical review of the observed vascular diseases, the proposed mechanism of atherosclerosis, and the benefits of treatment of psoriasis.",
keywords = "Atherosclerosis, Cardiovascular risk factors, Coronary artery disease, Myocardial infarction, Psoriasis, Systemic inflammation",
author = "Shelling, {Michael L.} and Federman, {Daniel G.} and Srdjan Prodanovich and Robert Kirsner",
year = "2008",
month = "5",
day = "1",
doi = "10.1016/j.amjmed.2008.01.025",
language = "English",
volume = "121",
pages = "360--365",
journal = "American Journal of Medicine",
issn = "0002-9343",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Psoriasis and Vascular Disease

T2 - An Unsolved Mystery

AU - Shelling, Michael L.

AU - Federman, Daniel G.

AU - Prodanovich, Srdjan

AU - Kirsner, Robert

PY - 2008/5/1

Y1 - 2008/5/1

N2 - Psoriasis is an immune disease most commonly recognized for its skin and joint manifestations. These produce significant physical, social, and psychological distress in affected patients and resultant reductions in their quality of life. As expected, these concerns are vital in providing symptomatic improvement and in selecting an individualized therapy. Yet, the approach in management of these patients is likely to change given the growing body of evidence linking psoriasis and vascular disease. Stemming from an anecdotally described relationship, the association between psoriasis and vascular disease has become a focus of current research to further elucidate the pathophysiology underlying and connecting these two diseases. This article includes a review of the classical cardiovascular risk factors, the atherothrombotic markers, and the environmental stressors associated with psoriasis, as well as a critical review of the observed vascular diseases, the proposed mechanism of atherosclerosis, and the benefits of treatment of psoriasis.

AB - Psoriasis is an immune disease most commonly recognized for its skin and joint manifestations. These produce significant physical, social, and psychological distress in affected patients and resultant reductions in their quality of life. As expected, these concerns are vital in providing symptomatic improvement and in selecting an individualized therapy. Yet, the approach in management of these patients is likely to change given the growing body of evidence linking psoriasis and vascular disease. Stemming from an anecdotally described relationship, the association between psoriasis and vascular disease has become a focus of current research to further elucidate the pathophysiology underlying and connecting these two diseases. This article includes a review of the classical cardiovascular risk factors, the atherothrombotic markers, and the environmental stressors associated with psoriasis, as well as a critical review of the observed vascular diseases, the proposed mechanism of atherosclerosis, and the benefits of treatment of psoriasis.

KW - Atherosclerosis

KW - Cardiovascular risk factors

KW - Coronary artery disease

KW - Myocardial infarction

KW - Psoriasis

KW - Systemic inflammation

UR - http://www.scopus.com/inward/record.url?scp=43049094410&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=43049094410&partnerID=8YFLogxK

U2 - 10.1016/j.amjmed.2008.01.025

DO - 10.1016/j.amjmed.2008.01.025

M3 - Article

VL - 121

SP - 360

EP - 365

JO - American Journal of Medicine

JF - American Journal of Medicine

SN - 0002-9343

IS - 5

ER -