Psoriasis and Vascular Disease: An Unsolved Mystery

Michael L. Shelling, Daniel G. Federman, Srdjan Prodanovich, Robert S. Kirsner

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


Psoriasis is an immune disease most commonly recognized for its skin and joint manifestations. These produce significant physical, social, and psychological distress in affected patients and resultant reductions in their quality of life. As expected, these concerns are vital in providing symptomatic improvement and in selecting an individualized therapy. Yet, the approach in management of these patients is likely to change given the growing body of evidence linking psoriasis and vascular disease. Stemming from an anecdotally described relationship, the association between psoriasis and vascular disease has become a focus of current research to further elucidate the pathophysiology underlying and connecting these two diseases. This article includes a review of the classical cardiovascular risk factors, the atherothrombotic markers, and the environmental stressors associated with psoriasis, as well as a critical review of the observed vascular diseases, the proposed mechanism of atherosclerosis, and the benefits of treatment of psoriasis.

Original languageEnglish (US)
Pages (from-to)360-365
Number of pages6
JournalAmerican Journal of Medicine
Issue number5
StatePublished - May 1 2008


  • Atherosclerosis
  • Cardiovascular risk factors
  • Coronary artery disease
  • Myocardial infarction
  • Psoriasis
  • Systemic inflammation

ASJC Scopus subject areas

  • Nursing(all)


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