Pseudo-gamma heavy chain (IgG4 lambda) deposition disease.

R. R. Tubbs, V. Berkley, R. Valenzuela, J. T. McMahon, G. N. Gephardt, A. J. Fishleder, J. V. Nally, M. A. Pohl, R. M. Bukowski, A. E. Lichtin

Research output: Contribution to journalArticle

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Abstract

Two patients with Ig deposition disease presented with acute renal failure, moderate proteinuria, and hematuria. A plasmacytoid lymphocytic infiltrate was identified in bone marrow that produced IgG4 lambda and free lambda light chains. One patient developed an anaplastic plasmacytoma (secreting only lambda light chains) 1 yr after renal biopsy. Renal biopsy in both patients demonstrated a nodular intercapillary glomerulopathy and electron dense granular deposits, associated with a linear pattern of IgG4 heavy chain deposition in vascular, tubular, and glomerular basement membranes (VBM, TBM, and GBM). In one patient this entrapped IgG4 was unassociated with detectable kappa or lambda light chains. In the second patient, lambda light chains (1+) were detected only in the GBM, but IgG4 (4+) was identified in GBM/TBM. Neither circulating (peripheral blood and bone marrow serum) nor cellular free gamma chains were present. We propose the term "pseudo-gamma heavy chain deposition disease" for the process.

Original languageEnglish
Pages (from-to)185-190
Number of pages6
JournalModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Volume5
Issue number2
StatePublished - Mar 1 1992
Externally publishedYes

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Immunoglobulin G
Light
Heavy Chain Disease
Bone Marrow
Kidney
Biopsy
Glomerular Basement Membrane
Hematuria
Proteinuria
Acute Kidney Injury
Blood Vessels
Electrons
Serum

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Tubbs, R. R., Berkley, V., Valenzuela, R., McMahon, J. T., Gephardt, G. N., Fishleder, A. J., ... Lichtin, A. E. (1992). Pseudo-gamma heavy chain (IgG4 lambda) deposition disease. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 5(2), 185-190.

Pseudo-gamma heavy chain (IgG4 lambda) deposition disease. / Tubbs, R. R.; Berkley, V.; Valenzuela, R.; McMahon, J. T.; Gephardt, G. N.; Fishleder, A. J.; Nally, J. V.; Pohl, M. A.; Bukowski, R. M.; Lichtin, A. E.

In: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 5, No. 2, 01.03.1992, p. 185-190.

Research output: Contribution to journalArticle

Tubbs, RR, Berkley, V, Valenzuela, R, McMahon, JT, Gephardt, GN, Fishleder, AJ, Nally, JV, Pohl, MA, Bukowski, RM & Lichtin, AE 1992, 'Pseudo-gamma heavy chain (IgG4 lambda) deposition disease.', Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, vol. 5, no. 2, pp. 185-190.
Tubbs RR, Berkley V, Valenzuela R, McMahon JT, Gephardt GN, Fishleder AJ et al. Pseudo-gamma heavy chain (IgG4 lambda) deposition disease. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 1992 Mar 1;5(2):185-190.
Tubbs, R. R. ; Berkley, V. ; Valenzuela, R. ; McMahon, J. T. ; Gephardt, G. N. ; Fishleder, A. J. ; Nally, J. V. ; Pohl, M. A. ; Bukowski, R. M. ; Lichtin, A. E. / Pseudo-gamma heavy chain (IgG4 lambda) deposition disease. In: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 1992 ; Vol. 5, No. 2. pp. 185-190.
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