Prurigo Nodularis and Its Management

Claudia Zeidler, Gil Yosipovitch, Sonja Ständer

Research output: Contribution to journalReview article

27 Scopus citations

Abstract

Prurigo nodularis occurs with chronic pruritus and the presence of single to multiple symmetrically distributed, hyperkeratotic, and intensively itching nodules. Diverse dermatologic, systemic, neurologic, or psychiatric conditions can lead to prurigo nodularis. Structural analysis demonstrated a reduced intraepidermal nerve fiber density and increased dermal levels of nerve growth factor and neuropeptides such as substance P and calcitonin gene-related peptide. Novel therapy concepts such as inhibitors at neurokinin-1, opioid receptors, and interleukin-31 receptors have been developed. The mainstays of prurigo nodularis therapy comprise topical steroids, capsaicin, calcineurin inhibitors, phototherapy, and the systemic application of anticonvulsants, μ-opioid receptor antagonists, or immunosuppressants.

Original languageEnglish (US)
Pages (from-to)189-197
Number of pages9
JournalDermatologic Clinics
Volume36
Issue number3
DOIs
StatePublished - Jul 1 2018

Keywords

  • Chronic pruritus
  • Itch
  • Prurigo nodularis
  • Pruritus
  • Scratch lesions
  • Therapy

ASJC Scopus subject areas

  • Dermatology

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