TY - JOUR
T1 - Prurigo Nodularis and Its Management
AU - Zeidler, Claudia
AU - Yosipovitch, Gil
AU - Ständer, Sonja
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Prurigo nodularis occurs with chronic pruritus and the presence of single to multiple symmetrically distributed, hyperkeratotic, and intensively itching nodules. Diverse dermatologic, systemic, neurologic, or psychiatric conditions can lead to prurigo nodularis. Structural analysis demonstrated a reduced intraepidermal nerve fiber density and increased dermal levels of nerve growth factor and neuropeptides such as substance P and calcitonin gene-related peptide. Novel therapy concepts such as inhibitors at neurokinin-1, opioid receptors, and interleukin-31 receptors have been developed. The mainstays of prurigo nodularis therapy comprise topical steroids, capsaicin, calcineurin inhibitors, phototherapy, and the systemic application of anticonvulsants, μ-opioid receptor antagonists, or immunosuppressants.
AB - Prurigo nodularis occurs with chronic pruritus and the presence of single to multiple symmetrically distributed, hyperkeratotic, and intensively itching nodules. Diverse dermatologic, systemic, neurologic, or psychiatric conditions can lead to prurigo nodularis. Structural analysis demonstrated a reduced intraepidermal nerve fiber density and increased dermal levels of nerve growth factor and neuropeptides such as substance P and calcitonin gene-related peptide. Novel therapy concepts such as inhibitors at neurokinin-1, opioid receptors, and interleukin-31 receptors have been developed. The mainstays of prurigo nodularis therapy comprise topical steroids, capsaicin, calcineurin inhibitors, phototherapy, and the systemic application of anticonvulsants, μ-opioid receptor antagonists, or immunosuppressants.
KW - Chronic pruritus
KW - Itch
KW - Prurigo nodularis
KW - Pruritus
KW - Scratch lesions
KW - Therapy
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U2 - 10.1016/j.det.2018.02.003
DO - 10.1016/j.det.2018.02.003
M3 - Review article
C2 - 29929592
AN - SCOPUS:85044138208
VL - 36
SP - 189
EP - 197
JO - Dermatologic Clinics
JF - Dermatologic Clinics
SN - 0733-8635
IS - 3
ER -