Abstract
Mood disorders are the most common psychiatric problem associated with Parkinson's disease (PD), and have a negative impact on disability and quality of life. Accurate diagnosis of depressive disturbances in PD is critical and will facilitate the testing and use of new interventions; however, there are no clear diagnostic criteria for depressive disorders in PD. In their current form, strict Diagnostic and Statistical Manual of Mental Disorders (DSM) criteria are difficult to use in PD and require attribution of specific symptoms to PD itself or the depressive syndrome. Additionally, DSM criteria for major depression and dysthymia exclude perhaps half of PD patients with comorbid clinically significant depression. This review summarizes an NIH-sponsored workshop and describes recommended changes to DSM diagnostic criteria for depression for use in PD. Participants also recommended: (1) an inclusive approach to symptom assessment to enhance reliability of ratings in PD and avoid the need to attribute symptoms to a particular cause; (2) the inclusion of subsyndromal depression in clinical research studies of depression of PD; (3) the specification of timing of assessments for PD patients with motor fluctuations; and (4) the use of informants for cognitively impaired patients. The proposed diagnostic criteria are provisional and intended to be defined further and validated but provide a common starting point for clinical research in PD-associated depression.
| Original language | English |
|---|---|
| Pages (from-to) | 148-158 |
| Number of pages | 11 |
| Journal | Movement Disorders |
| Volume | 21 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2006 |
| Externally published | Yes |
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Keywords
- Affective symptoms
- Depression
- Diagnosis
- Mood disorders
- Parkinson's disease
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Provisional diagnostic criteria for depression in Parkinson's disease : Report of an NINDS/NIMH Work Group. / Marsh, Laura; McDonald, William M.; Cummings, Jeffrey; Ravina, Bernard; Abraham, Nancy; Babcock, Debra J.; Black, Kevin J.; Burn, David; Como, Peter; Cummings, Jeffrey; Edwards, Emmeline; Elliott, Robin; Friedman, Joseph; Gwinn-Hardy, Katrina; Hamer, Robert M.; Kelley, Melinda; Levin, Bonnie; Lyketsos, Constantine G.; Lyness, Jeffrey M.; Marder, Karen S.; Menza, Mathew; Morin, Lynn; Muehrer, Peter; Murphy, Diane; Richard, Irene; Sheehy, Paul; Spitzer, Robert L.; Stone, Sharon; Tucker, Brenda; Tuchman, Margaret; Walton, Carol; Weintraub, Daniel; Williams, James R.; Zalutsky, Robert.
In: Movement Disorders, Vol. 21, No. 2, 01.02.2006, p. 148-158.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Provisional diagnostic criteria for depression in Parkinson's disease
T2 - Report of an NINDS/NIMH Work Group
AU - Marsh, Laura
AU - McDonald, William M.
AU - Cummings, Jeffrey
AU - Ravina, Bernard
AU - Abraham, Nancy
AU - Babcock, Debra J.
AU - Black, Kevin J.
AU - Burn, David
AU - Como, Peter
AU - Cummings, Jeffrey
AU - Edwards, Emmeline
AU - Elliott, Robin
AU - Friedman, Joseph
AU - Gwinn-Hardy, Katrina
AU - Hamer, Robert M.
AU - Kelley, Melinda
AU - Levin, Bonnie
AU - Lyketsos, Constantine G.
AU - Lyness, Jeffrey M.
AU - Marder, Karen S.
AU - Menza, Mathew
AU - Morin, Lynn
AU - Muehrer, Peter
AU - Murphy, Diane
AU - Richard, Irene
AU - Sheehy, Paul
AU - Spitzer, Robert L.
AU - Stone, Sharon
AU - Tucker, Brenda
AU - Tuchman, Margaret
AU - Walton, Carol
AU - Weintraub, Daniel
AU - Williams, James R.
AU - Zalutsky, Robert
PY - 2006/2/1
Y1 - 2006/2/1
N2 - Mood disorders are the most common psychiatric problem associated with Parkinson's disease (PD), and have a negative impact on disability and quality of life. Accurate diagnosis of depressive disturbances in PD is critical and will facilitate the testing and use of new interventions; however, there are no clear diagnostic criteria for depressive disorders in PD. In their current form, strict Diagnostic and Statistical Manual of Mental Disorders (DSM) criteria are difficult to use in PD and require attribution of specific symptoms to PD itself or the depressive syndrome. Additionally, DSM criteria for major depression and dysthymia exclude perhaps half of PD patients with comorbid clinically significant depression. This review summarizes an NIH-sponsored workshop and describes recommended changes to DSM diagnostic criteria for depression for use in PD. Participants also recommended: (1) an inclusive approach to symptom assessment to enhance reliability of ratings in PD and avoid the need to attribute symptoms to a particular cause; (2) the inclusion of subsyndromal depression in clinical research studies of depression of PD; (3) the specification of timing of assessments for PD patients with motor fluctuations; and (4) the use of informants for cognitively impaired patients. The proposed diagnostic criteria are provisional and intended to be defined further and validated but provide a common starting point for clinical research in PD-associated depression.
AB - Mood disorders are the most common psychiatric problem associated with Parkinson's disease (PD), and have a negative impact on disability and quality of life. Accurate diagnosis of depressive disturbances in PD is critical and will facilitate the testing and use of new interventions; however, there are no clear diagnostic criteria for depressive disorders in PD. In their current form, strict Diagnostic and Statistical Manual of Mental Disorders (DSM) criteria are difficult to use in PD and require attribution of specific symptoms to PD itself or the depressive syndrome. Additionally, DSM criteria for major depression and dysthymia exclude perhaps half of PD patients with comorbid clinically significant depression. This review summarizes an NIH-sponsored workshop and describes recommended changes to DSM diagnostic criteria for depression for use in PD. Participants also recommended: (1) an inclusive approach to symptom assessment to enhance reliability of ratings in PD and avoid the need to attribute symptoms to a particular cause; (2) the inclusion of subsyndromal depression in clinical research studies of depression of PD; (3) the specification of timing of assessments for PD patients with motor fluctuations; and (4) the use of informants for cognitively impaired patients. The proposed diagnostic criteria are provisional and intended to be defined further and validated but provide a common starting point for clinical research in PD-associated depression.
KW - Affective symptoms
KW - Depression
KW - Diagnosis
KW - Mood disorders
KW - Parkinson's disease
UR - http://www.scopus.com/inward/record.url?scp=33644938238&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33644938238&partnerID=8YFLogxK
U2 - 10.1002/mds.20723
DO - 10.1002/mds.20723
M3 - Article
C2 - 16211591
AN - SCOPUS:33644938238
VL - 21
SP - 148
EP - 158
JO - Movement Disorders
JF - Movement Disorders
SN - 0885-3185
IS - 2
ER -