Proton‐decoupled 31P chemical shift imaging of the human brain in normal volunteers

Joseph Murphy‐Boesch, Radka Stoyanova, Ravi Srinivasan, Tamela Willard, Daniel Vigneron, Sarah Nelson, June S. Taylor, Truman R. Brown

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74 Scopus citations

Abstract

Proton-decoupled, 31P three-dimensional (3-D) chemical shift imaging (CSI) spectra have been acquired from the entire human brain using a new dual tuned resonator. The resonator operates in quadrature mode to provide improved sensitivity, excellent B1 homogeneity and reduced power deposition at both frequencies. Proton-decoupled and fully NOE enhanced, 31P spectra were acquired from normal volunteers using Waltz-4 proton decoupling with continuous wave bi-level excitation applied through a second radio frequency channel. Well resolved peaks in the phosphomonoester (PME) and phosphodiester regions were obtained from nonlocalized FIDs and spectra localized with 3-D CSI without processing for resolution enhancement. pH measurements made over large regions of the brain using the P(i) resonance show no significant variations (6.9 +/- 0.02) for a single individual. The improved spectral resolution and sensitivity of the PME resonances results in more well defined metabolite images of the PME peak region.

Original languageEnglish (US)
Pages (from-to)173-180
Number of pages8
JournalNMR in biomedicine
Volume6
Issue number3
DOIs
StatePublished - Jan 1 1993

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ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Spectroscopy

Cite this

Murphy‐Boesch, J., Stoyanova, R., Srinivasan, R., Willard, T., Vigneron, D., Nelson, S., Taylor, J. S., & Brown, T. R. (1993). Proton‐decoupled 31P chemical shift imaging of the human brain in normal volunteers. NMR in biomedicine, 6(3), 173-180. https://doi.org/10.1002/nbm.1940060302