Proton relaxation times in arterial wall and atheromatous lesions in man

Kalevi Soila, Pentti Nummi, Tauno Ekfors, Manuel Viamonte, Martti Kormano

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

The proton relaxation times of autopsy samples of arterial intima-media were measured with an NMR spectrometer and results correlated to the microscopically estimated lipid content of the vascular wall. The normal arterial intima-media contained two T1 relaxation components. The short T1 component (Tls) was 90 ± 13 ms and its relative weight was 11%. The long T1 component (Til) was 523 ± 89 ms and relative weight 88%, respectively. The average T2 was 99 ± 18 ms. In diseased vessels, a positive correlation was found between the lipid content of the vessel wall and the relaxation rate of the fast component. Tls of the intima-media was significantly shorter (P <.01) in severe atheromatosis compared with vessels without fat deposition. The results suggest that atheromatous lesions should be best highlighted in spin-echo images by using short TR and TE to suppress the influence of Til and to avoid (noncontrast contributing) T2 decay of the signal intensity.

Original languageEnglish (US)
Pages (from-to)411-415
Number of pages5
JournalInvestigative Radiology
Volume21
Issue number5
DOIs
StatePublished - May 1986

Keywords

  • Atheromatosis
  • Magnetic resonance imaging
  • Nuclear magnetic resonance studies
  • Proton relaxation times
  • Vascular system

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Proton relaxation times in arterial wall and atheromatous lesions in man'. Together they form a unique fingerprint.

  • Cite this