Proton NMR chemical shifts and coupling constants for brain metabolites

Research output: Contribution to journalArticle

1106 Citations (Scopus)

Abstract

Proton NMR chemical shift and J-coupling values are presented for 35 metabolites that can be detected by in vivo or in vitro NMR studies of mammalian brain. Measurements were obtained using high-field NMR spectra of metabolites in solution, under conditions typical for normal physiological temperature and pH. This information is presented with an accuracy that is suitable for computer simulation of metabolite spectra to be used as basis functions of a parametric spectral analysis procedure. This procedure is verified by the analysis of a rat brain extract spectrum, using the measured spectral parameters. In addition, the metabolite structures and example spectra are presented, and clinical applications and MR spectroscopic measurements of these metabolites are reviewed. Copyright (C) 2000 John Wiley and Sons, Ltd.

Original languageEnglish
Pages (from-to)129-153
Number of pages25
JournalNMR in Biomedicine
Volume13
Issue number3
DOIs
StatePublished - May 1 2000
Externally publishedYes

Fingerprint

Chemical shift
Metabolites
Protons
Brain
Nuclear magnetic resonance
Computer Simulation
Temperature
Spectrum analysis
Rats
Computer simulation
In Vitro Techniques

Keywords

  • Brain metabolites
  • Chemical shifts
  • Coupling constants
  • In vivo
  • Nuclear magnetic resonance spectroscopy
  • Parametric spectral analysis
  • Proton
  • Review

ASJC Scopus subject areas

  • Spectroscopy
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Biophysics

Cite this

Proton NMR chemical shifts and coupling constants for brain metabolites. / Govind, Varan; Young, Karl; Maudsley, Andrew A.

In: NMR in Biomedicine, Vol. 13, No. 3, 01.05.2000, p. 129-153.

Research output: Contribution to journalArticle

@article{7313aff1fef049d7b4e8975b5f319c87,
title = "Proton NMR chemical shifts and coupling constants for brain metabolites",
abstract = "Proton NMR chemical shift and J-coupling values are presented for 35 metabolites that can be detected by in vivo or in vitro NMR studies of mammalian brain. Measurements were obtained using high-field NMR spectra of metabolites in solution, under conditions typical for normal physiological temperature and pH. This information is presented with an accuracy that is suitable for computer simulation of metabolite spectra to be used as basis functions of a parametric spectral analysis procedure. This procedure is verified by the analysis of a rat brain extract spectrum, using the measured spectral parameters. In addition, the metabolite structures and example spectra are presented, and clinical applications and MR spectroscopic measurements of these metabolites are reviewed. Copyright (C) 2000 John Wiley and Sons, Ltd.",
keywords = "Brain metabolites, Chemical shifts, Coupling constants, In vivo, Nuclear magnetic resonance spectroscopy, Parametric spectral analysis, Proton, Review",
author = "Varan Govind and Karl Young and Maudsley, {Andrew A}",
year = "2000",
month = "5",
day = "1",
doi = "10.1002/1099-1492(200005)13:3<129::AID-NBM619>3.0.CO;2-V",
language = "English",
volume = "13",
pages = "129--153",
journal = "NMR in Biomedicine",
issn = "0952-3480",
publisher = "John Wiley and Sons Ltd",
number = "3",

}

TY - JOUR

T1 - Proton NMR chemical shifts and coupling constants for brain metabolites

AU - Govind, Varan

AU - Young, Karl

AU - Maudsley, Andrew A

PY - 2000/5/1

Y1 - 2000/5/1

N2 - Proton NMR chemical shift and J-coupling values are presented for 35 metabolites that can be detected by in vivo or in vitro NMR studies of mammalian brain. Measurements were obtained using high-field NMR spectra of metabolites in solution, under conditions typical for normal physiological temperature and pH. This information is presented with an accuracy that is suitable for computer simulation of metabolite spectra to be used as basis functions of a parametric spectral analysis procedure. This procedure is verified by the analysis of a rat brain extract spectrum, using the measured spectral parameters. In addition, the metabolite structures and example spectra are presented, and clinical applications and MR spectroscopic measurements of these metabolites are reviewed. Copyright (C) 2000 John Wiley and Sons, Ltd.

AB - Proton NMR chemical shift and J-coupling values are presented for 35 metabolites that can be detected by in vivo or in vitro NMR studies of mammalian brain. Measurements were obtained using high-field NMR spectra of metabolites in solution, under conditions typical for normal physiological temperature and pH. This information is presented with an accuracy that is suitable for computer simulation of metabolite spectra to be used as basis functions of a parametric spectral analysis procedure. This procedure is verified by the analysis of a rat brain extract spectrum, using the measured spectral parameters. In addition, the metabolite structures and example spectra are presented, and clinical applications and MR spectroscopic measurements of these metabolites are reviewed. Copyright (C) 2000 John Wiley and Sons, Ltd.

KW - Brain metabolites

KW - Chemical shifts

KW - Coupling constants

KW - In vivo

KW - Nuclear magnetic resonance spectroscopy

KW - Parametric spectral analysis

KW - Proton

KW - Review

UR - http://www.scopus.com/inward/record.url?scp=0034099574&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034099574&partnerID=8YFLogxK

U2 - 10.1002/1099-1492(200005)13:3<129::AID-NBM619>3.0.CO;2-V

DO - 10.1002/1099-1492(200005)13:3<129::AID-NBM619>3.0.CO;2-V

M3 - Article

C2 - 10861994

AN - SCOPUS:0034099574

VL - 13

SP - 129

EP - 153

JO - NMR in Biomedicine

JF - NMR in Biomedicine

SN - 0952-3480

IS - 3

ER -