Proton MR spectroscopy of gliomatosis cerebri: Case report of elevated myoinositol with normal choline levels

Efrat Saraf-Lavi; Brian C. Bowen; Pradip M. Pattany; Evelyn M.L. Sklar; James B. Murdoch; Carol K. Petito

Proton MR spectroscopy of gliomatosis cerebri: Case report of elevated myoinositol with normal choline levels

Efrat Saraf-Lavi, Brian C. Bowen, Pradip M. Pattany, Evelyn M.L. Sklar, James B. Murdoch, Carol K. Petito

Research output: Contribution to journal › Article › peer-review

Abstract

A 69-year-old woman presented with clinical and imaging findings suspicious for gliomatosis cerebri, later confirmed by biopsy (moderately cellular, infiltrating glioma). Single voxel proton MR spectroscopy (TE 20 and TE 135) and spectroscopic imaging (TE 135) performed at admission showed normal choline, decreased N-acetyl, and elevated myo-inositol levels relative to creatine. The primary conclusion is that in suspected cases of gliomatosis cerebri, myo-inositol/creatine and myo-inositol/N-acetyl should be determined because they may provide evidence of tumor, even though choline/creatine is normal. A corollary to this conclusion is that choline/creatine may be misleading if used to demarcate infiltrating glioma from edema.

Original language	English (US)
Pages (from-to)	946-951
Number of pages	6
Journal	American Journal of Neuroradiology
Volume	24
Issue number	5
State	Published - May 1 2003

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Clinical Neurology

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Proton MR spectroscopy of gliomatosis cerebri : Case report of elevated myoinositol with normal choline levels. / Saraf-Lavi, Efrat; Bowen, Brian C.; Pattany, Pradip M.; Sklar, Evelyn M.L.; Murdoch, James B.; Petito, Carol K.

In: American Journal of Neuroradiology, Vol. 24, No. 5, 01.05.2003, p. 946-951.

Research output: Contribution to journal › Article › peer-review

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abstract = "A 69-year-old woman presented with clinical and imaging findings suspicious for gliomatosis cerebri, later confirmed by biopsy (moderately cellular, infiltrating glioma). Single voxel proton MR spectroscopy (TE 20 and TE 135) and spectroscopic imaging (TE 135) performed at admission showed normal choline, decreased N-acetyl, and elevated myo-inositol levels relative to creatine. The primary conclusion is that in suspected cases of gliomatosis cerebri, myo-inositol/creatine and myo-inositol/N-acetyl should be determined because they may provide evidence of tumor, even though choline/creatine is normal. A corollary to this conclusion is that choline/creatine may be misleading if used to demarcate infiltrating glioma from edema.",

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