Proton MR spectroscopy of gliomatosis cerebri: Case report of elevated myoinositol with normal choline levels

Efrat Saraf Lavi, Brian C. Bowen, Pradip Pattany, Evelyn Sklar, James B. Murdoch, Carol Petito

Research output: Contribution to journalArticle

50 Scopus citations


A 69-year-old woman presented with clinical and imaging findings suspicious for gliomatosis cerebri, later confirmed by biopsy (moderately cellular, infiltrating glioma). Single voxel proton MR spectroscopy (TE 20 and TE 135) and spectroscopic imaging (TE 135) performed at admission showed normal choline, decreased N-acetyl, and elevated myo-inositol levels relative to creatine. The primary conclusion is that in suspected cases of gliomatosis cerebri, myo-inositol/creatine and myo-inositol/N-acetyl should be determined because they may provide evidence of tumor, even though choline/creatine is normal. A corollary to this conclusion is that choline/creatine may be misleading if used to demarcate infiltrating glioma from edema.

Original languageEnglish
Pages (from-to)946-951
Number of pages6
JournalAmerican Journal of Neuroradiology
Issue number5
StatePublished - May 1 2003


ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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