Proton MR spectroscopy in metabolic assessment of musculoskeletal lesions

Ty Subhawong, Xin Wang, Daniel J. Durand, Michael A. Jacobs, John A. Carrino, Antonio J. Machado, Laura M. Fayad

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

OBJECTIVE. The purposes of this review are to describe the principles and method of MR spectroscopy, summarize current published data on musculoskeletal lesions, and report additional cases that have been analyzed with recently developed quantitative methods. CONCLUSION. Proton MR spectroscopy can be used to identify key tissue metabolites and may serve as a useful adjunct to radiographic evaluation of musculoskeletal lesions. A pooled analysis of 122 musculoskeletal tumors revealed that a discrete choline peak has a sensitivity of 88% and specificity of 68% in the detection of malignancy. Modest improvements in diagnostic accuracy in 22 of 122 cases when absolute choline quantification was used encourage the pursuit of development of choline quantification methods.

Original languageEnglish
Pages (from-to)162-172
Number of pages11
JournalAmerican Journal of Roentgenology
Volume198
Issue number1
DOIs
StatePublished - Jan 1 2012
Externally publishedYes

Fingerprint

Choline
Protons
Magnetic Resonance Spectroscopy
Neoplasms
Sensitivity and Specificity

Keywords

  • Choline
  • MR spectroscopy
  • MRI
  • Musculoskeletal
  • Tumor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Subhawong, T., Wang, X., Durand, D. J., Jacobs, M. A., Carrino, J. A., Machado, A. J., & Fayad, L. M. (2012). Proton MR spectroscopy in metabolic assessment of musculoskeletal lesions. American Journal of Roentgenology, 198(1), 162-172. https://doi.org/10.2214/AJR.11.6505

Proton MR spectroscopy in metabolic assessment of musculoskeletal lesions. / Subhawong, Ty; Wang, Xin; Durand, Daniel J.; Jacobs, Michael A.; Carrino, John A.; Machado, Antonio J.; Fayad, Laura M.

In: American Journal of Roentgenology, Vol. 198, No. 1, 01.01.2012, p. 162-172.

Research output: Contribution to journalArticle

Subhawong, T, Wang, X, Durand, DJ, Jacobs, MA, Carrino, JA, Machado, AJ & Fayad, LM 2012, 'Proton MR spectroscopy in metabolic assessment of musculoskeletal lesions', American Journal of Roentgenology, vol. 198, no. 1, pp. 162-172. https://doi.org/10.2214/AJR.11.6505
Subhawong, Ty ; Wang, Xin ; Durand, Daniel J. ; Jacobs, Michael A. ; Carrino, John A. ; Machado, Antonio J. ; Fayad, Laura M. / Proton MR spectroscopy in metabolic assessment of musculoskeletal lesions. In: American Journal of Roentgenology. 2012 ; Vol. 198, No. 1. pp. 162-172.
@article{e41a1ef5d21245efafa575819134876a,
title = "Proton MR spectroscopy in metabolic assessment of musculoskeletal lesions",
abstract = "OBJECTIVE. The purposes of this review are to describe the principles and method of MR spectroscopy, summarize current published data on musculoskeletal lesions, and report additional cases that have been analyzed with recently developed quantitative methods. CONCLUSION. Proton MR spectroscopy can be used to identify key tissue metabolites and may serve as a useful adjunct to radiographic evaluation of musculoskeletal lesions. A pooled analysis of 122 musculoskeletal tumors revealed that a discrete choline peak has a sensitivity of 88{\%} and specificity of 68{\%} in the detection of malignancy. Modest improvements in diagnostic accuracy in 22 of 122 cases when absolute choline quantification was used encourage the pursuit of development of choline quantification methods.",
keywords = "Choline, MR spectroscopy, MRI, Musculoskeletal, Tumor",
author = "Ty Subhawong and Xin Wang and Durand, {Daniel J.} and Jacobs, {Michael A.} and Carrino, {John A.} and Machado, {Antonio J.} and Fayad, {Laura M.}",
year = "2012",
month = "1",
day = "1",
doi = "10.2214/AJR.11.6505",
language = "English",
volume = "198",
pages = "162--172",
journal = "AJR. American journal of roentgenology",
issn = "0361-803X",
publisher = "American Roentgen Ray Society",
number = "1",

}

TY - JOUR

T1 - Proton MR spectroscopy in metabolic assessment of musculoskeletal lesions

AU - Subhawong, Ty

AU - Wang, Xin

AU - Durand, Daniel J.

AU - Jacobs, Michael A.

AU - Carrino, John A.

AU - Machado, Antonio J.

AU - Fayad, Laura M.

PY - 2012/1/1

Y1 - 2012/1/1

N2 - OBJECTIVE. The purposes of this review are to describe the principles and method of MR spectroscopy, summarize current published data on musculoskeletal lesions, and report additional cases that have been analyzed with recently developed quantitative methods. CONCLUSION. Proton MR spectroscopy can be used to identify key tissue metabolites and may serve as a useful adjunct to radiographic evaluation of musculoskeletal lesions. A pooled analysis of 122 musculoskeletal tumors revealed that a discrete choline peak has a sensitivity of 88% and specificity of 68% in the detection of malignancy. Modest improvements in diagnostic accuracy in 22 of 122 cases when absolute choline quantification was used encourage the pursuit of development of choline quantification methods.

AB - OBJECTIVE. The purposes of this review are to describe the principles and method of MR spectroscopy, summarize current published data on musculoskeletal lesions, and report additional cases that have been analyzed with recently developed quantitative methods. CONCLUSION. Proton MR spectroscopy can be used to identify key tissue metabolites and may serve as a useful adjunct to radiographic evaluation of musculoskeletal lesions. A pooled analysis of 122 musculoskeletal tumors revealed that a discrete choline peak has a sensitivity of 88% and specificity of 68% in the detection of malignancy. Modest improvements in diagnostic accuracy in 22 of 122 cases when absolute choline quantification was used encourage the pursuit of development of choline quantification methods.

KW - Choline

KW - MR spectroscopy

KW - MRI

KW - Musculoskeletal

KW - Tumor

UR - http://www.scopus.com/inward/record.url?scp=84455209470&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84455209470&partnerID=8YFLogxK

U2 - 10.2214/AJR.11.6505

DO - 10.2214/AJR.11.6505

M3 - Article

C2 - 22194493

AN - SCOPUS:84455209470

VL - 198

SP - 162

EP - 172

JO - AJR. American journal of roentgenology

JF - AJR. American journal of roentgenology

SN - 0361-803X

IS - 1

ER -