Proton magnetic resonance spectroscopy of the thalamus in patients with chronic neuropathic pain after spinal cord injury

Pradip Pattany, Robert P. Yezierski, Eva Widerstrom-Noga, Brian C. Bowen, Alberto Martinez-Arizala, Bernardo R. Garcia, Robert Quencer

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: Spinal cord injury (SCI) results in a number of consequences; one of the most difficult to manage is chronic neuropathic pain. Thus, defining the potential neural and biochemical changes associated with chronic pain after SCI is important because this may lead to development of new treatment strategies. Prior studies have looked at the thalamus, because it is a major sensory relay station. The purpose of our study was to define alterations in metabolites due to injury-induced functional changes in thalamic nuclei by using single-voxel stimulated echo acquisition mode MR spectroscopy. METHODS: Twenty-six men were recruited: 16 patients with SCI and paraplegia (seven with pain, nine without pain) and 10 healthy control subjects. Pain was evaluated in an interview, which included the collection of information concerning the location, quality, and intensity of pain, carefully identifing the dysesthetic neuropathic pain often seen in SCI. Localized single-voxel (8-cm3 volume) proton spectra were acquired from the left and right thalami. RESULTS: The concentration of N-acetyl (NA) was negatively correlated with pain intensity (r = -0.678), and the t test showed that NA was significantly different between patients with pain and patients without pain (P = .006). Myo-inositol was positively correlated with pain intensity (r = 0.520); difference between patients with pain and those without pain was almost significant (P = .06). CONCLUSION: The observed differences in metabolites in SCI patients with and pain and in those without pain suggest anatomic, functional, and biochemical changes in the thalamic region.

Original languageEnglish
Pages (from-to)901-905
Number of pages5
JournalAmerican Journal of Neuroradiology
Volume23
Issue number6
StatePublished - Jul 2 2002

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Neuralgia
Thalamus
Spinal Cord Injuries
Chronic Pain
Pain
Proton Magnetic Resonance Spectroscopy
Thalamic Nuclei
Paraplegia
Inositol
Protons
Healthy Volunteers
Magnetic Resonance Spectroscopy
Interviews

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Proton magnetic resonance spectroscopy of the thalamus in patients with chronic neuropathic pain after spinal cord injury. / Pattany, Pradip; Yezierski, Robert P.; Widerstrom-Noga, Eva; Bowen, Brian C.; Martinez-Arizala, Alberto; Garcia, Bernardo R.; Quencer, Robert.

In: American Journal of Neuroradiology, Vol. 23, No. 6, 02.07.2002, p. 901-905.

Research output: Contribution to journalArticle

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