Proton magnetic resonance spectroscopic imaging in neurodegenerative diseases

Norbert Schuff, Peter Vermathen, Andrew A. Maudsley, Michael W. Weiner

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Proton magnetic resonance spectroscopic imaging (1H MRSI) was used to investigate changes in brain metabolites in Alzheimer's disease, epilepsy, and amyotrophic lateral sclerosis. Examples of results from several ongoing clinical studies are provided. Multislice 1H MRSI of the human brain, without volume preselection offers considerable advantage over previously available techniques. Furthermore, MRI tissue segmentation and completely automated spectral curve fitting greatly facilitate quantitative data analysis. Future efforts will be devoted to obtain full volumetric brain coverage and data acquisition at short spin-echo times (TE < 30 ms) for the detection of metabolites.

Original languageEnglish (US)
Pages (from-to)800-807
Number of pages8
JournalCurrent Science
Issue number6
StatePublished - Mar 25 1999
Externally publishedYes

ASJC Scopus subject areas

  • General


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