Proton magnetic resonance spectroscopic imaging in neurodegenerative diseases

Norbert Schuff; Peter Vermathen; Andrew A. Maudsley; Michael W. Weiner

Proton magnetic resonance spectroscopic imaging in neurodegenerative diseases

Norbert Schuff, Peter Vermathen, Andrew A. Maudsley, Michael W. Weiner

Research output: Contribution to journal › Article › peer-review

Abstract

Proton magnetic resonance spectroscopic imaging (¹H MRSI) was used to investigate changes in brain metabolites in Alzheimer's disease, epilepsy, and amyotrophic lateral sclerosis. Examples of results from several ongoing clinical studies are provided. Multislice ¹H MRSI of the human brain, without volume preselection offers considerable advantage over previously available techniques. Furthermore, MRI tissue segmentation and completely automated spectral curve fitting greatly facilitate quantitative data analysis. Future efforts will be devoted to obtain full volumetric brain coverage and data acquisition at short spin-echo times (TE < 30 ms) for the detection of metabolites.

Original language	English (US)
Pages (from-to)	800-807
Number of pages	8
Journal	Current Science
Volume	76
Issue number	6
State	Published - Mar 25 1999
Externally published	Yes

ASJC Scopus subject areas

General

Fingerprint Dive into the research topics of 'Proton magnetic resonance spectroscopic imaging in neurodegenerative diseases'. Together they form a unique fingerprint.

Cite this

@article{0c38a5ae2a19474999f23bad6407676f,

title = "Proton magnetic resonance spectroscopic imaging in neurodegenerative diseases",

abstract = "Proton magnetic resonance spectroscopic imaging (1H MRSI) was used to investigate changes in brain metabolites in Alzheimer's disease, epilepsy, and amyotrophic lateral sclerosis. Examples of results from several ongoing clinical studies are provided. Multislice 1H MRSI of the human brain, without volume preselection offers considerable advantage over previously available techniques. Furthermore, MRI tissue segmentation and completely automated spectral curve fitting greatly facilitate quantitative data analysis. Future efforts will be devoted to obtain full volumetric brain coverage and data acquisition at short spin-echo times (TE < 30 ms) for the detection of metabolites.",

author = "Norbert Schuff and Peter Vermathen and Maudsley, {Andrew A.} and Weiner, {Michael W.}",

year = "1999",

month = mar,

day = "25",

language = "English (US)",

volume = "76",

pages = "800--807",

journal = "Current Science",

issn = "0011-3891",

publisher = "Indian Academy of Sciences",

number = "6",

}

TY - JOUR

T1 - Proton magnetic resonance spectroscopic imaging in neurodegenerative diseases

AU - Schuff, Norbert

AU - Vermathen, Peter

AU - Maudsley, Andrew A.

AU - Weiner, Michael W.

PY - 1999/3/25

Y1 - 1999/3/25

N2 - Proton magnetic resonance spectroscopic imaging (1H MRSI) was used to investigate changes in brain metabolites in Alzheimer's disease, epilepsy, and amyotrophic lateral sclerosis. Examples of results from several ongoing clinical studies are provided. Multislice 1H MRSI of the human brain, without volume preselection offers considerable advantage over previously available techniques. Furthermore, MRI tissue segmentation and completely automated spectral curve fitting greatly facilitate quantitative data analysis. Future efforts will be devoted to obtain full volumetric brain coverage and data acquisition at short spin-echo times (TE < 30 ms) for the detection of metabolites.

AB - Proton magnetic resonance spectroscopic imaging (1H MRSI) was used to investigate changes in brain metabolites in Alzheimer's disease, epilepsy, and amyotrophic lateral sclerosis. Examples of results from several ongoing clinical studies are provided. Multislice 1H MRSI of the human brain, without volume preselection offers considerable advantage over previously available techniques. Furthermore, MRI tissue segmentation and completely automated spectral curve fitting greatly facilitate quantitative data analysis. Future efforts will be devoted to obtain full volumetric brain coverage and data acquisition at short spin-echo times (TE < 30 ms) for the detection of metabolites.

UR - http://www.scopus.com/inward/record.url?scp=0042283220&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0042283220&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0042283220

VL - 76

SP - 800

EP - 807

JO - Current Science

JF - Current Science

SN - 0011-3891

IS - 6

ER -