Proton magnetic resonance spectroscopic imaging in neurodegenerative diseases

Norbert Schuff; Peter Vermathen; Andrew A. Maudsley; Michael W. Weiner

Proton magnetic resonance spectroscopic imaging in neurodegenerative diseases

Norbert Schuff, Peter Vermathen, Andrew A. Maudsley, Michael W. Weiner

Research output: Contribution to journal › Article › peer-review

Abstract

Proton magnetic resonance spectroscopic imaging (¹H MRSI) was used to investigate changes in brain metabolites in Alzheimer's disease, epilepsy, and amyotrophic lateral sclerosis. Examples of results from several ongoing clinical studies are provided. Multislice ¹H MRSI of the human brain, without volume preselection offers considerable advantage over previously available techniques. Furthermore, MRI tissue segmentation and completely automated spectral curve fitting greatly facilitate quantitative data analysis. Future efforts will be devoted to obtain full volumetric brain coverage and data acquisition at short spin-echo times (TE < 30 ms) for the detection of metabolites.

Original language	English (US)
Pages (from-to)	800-807
Number of pages	8
Journal	Current Science
Volume	76
Issue number	6
State	Published - Mar 25 1999
Externally published	Yes

ASJC Scopus subject areas

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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AU - Maudsley, Andrew A.

AU - Weiner, Michael W.

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AB - Proton magnetic resonance spectroscopic imaging (1H MRSI) was used to investigate changes in brain metabolites in Alzheimer's disease, epilepsy, and amyotrophic lateral sclerosis. Examples of results from several ongoing clinical studies are provided. Multislice 1H MRSI of the human brain, without volume preselection offers considerable advantage over previously available techniques. Furthermore, MRI tissue segmentation and completely automated spectral curve fitting greatly facilitate quantitative data analysis. Future efforts will be devoted to obtain full volumetric brain coverage and data acquisition at short spin-echo times (TE < 30 ms) for the detection of metabolites.

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Proton magnetic resonance spectroscopic imaging in neurodegenerative diseases

Abstract

ASJC Scopus subject areas

UN SDGs

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