Abstract
Proton magnetic resonance spectroscopic imaging (1H MRSI) was used to investigate changes in brain metabolites in Alzheimer's disease, epilepsy, and amyotrophic lateral sclerosis. Examples of results from several ongoing clinical studies are provided. Multislice 1H MRSI of the human brain, without volume preselection offers considerable advantage over previously available techniques. Furthermore, MRI tissue segmentation and completely automated spectral curve fitting greatly facilitate quantitative data analysis. Future efforts will be devoted to obtain full volumetric brain coverage and data acquisition at short spin-echo times (TE < 30 ms) for the detection of metabolites.
| Original language | English |
|---|---|
| Pages (from-to) | 800-807 |
| Number of pages | 8 |
| Journal | Current Science |
| Volume | 76 |
| Issue number | 6 |
| State | Published - Mar 25 1999 |
| Externally published | Yes |
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ASJC Scopus subject areas
- General
- Agricultural and Biological Sciences(all)
Cite this
Proton magnetic resonance spectroscopic imaging in neurodegenerative diseases. / Schuff, Norbert; Vermathen, Peter; Maudsley, Andrew A; Weiner, Michael W.
In: Current Science, Vol. 76, No. 6, 25.03.1999, p. 800-807.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Proton magnetic resonance spectroscopic imaging in neurodegenerative diseases
AU - Schuff, Norbert
AU - Vermathen, Peter
AU - Maudsley, Andrew A
AU - Weiner, Michael W.
PY - 1999/3/25
Y1 - 1999/3/25
N2 - Proton magnetic resonance spectroscopic imaging (1H MRSI) was used to investigate changes in brain metabolites in Alzheimer's disease, epilepsy, and amyotrophic lateral sclerosis. Examples of results from several ongoing clinical studies are provided. Multislice 1H MRSI of the human brain, without volume preselection offers considerable advantage over previously available techniques. Furthermore, MRI tissue segmentation and completely automated spectral curve fitting greatly facilitate quantitative data analysis. Future efforts will be devoted to obtain full volumetric brain coverage and data acquisition at short spin-echo times (TE < 30 ms) for the detection of metabolites.
AB - Proton magnetic resonance spectroscopic imaging (1H MRSI) was used to investigate changes in brain metabolites in Alzheimer's disease, epilepsy, and amyotrophic lateral sclerosis. Examples of results from several ongoing clinical studies are provided. Multislice 1H MRSI of the human brain, without volume preselection offers considerable advantage over previously available techniques. Furthermore, MRI tissue segmentation and completely automated spectral curve fitting greatly facilitate quantitative data analysis. Future efforts will be devoted to obtain full volumetric brain coverage and data acquisition at short spin-echo times (TE < 30 ms) for the detection of metabolites.
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UR - http://www.scopus.com/inward/citedby.url?scp=0042283220&partnerID=8YFLogxK
M3 - Article
VL - 76
SP - 800
EP - 807
JO - Current Science
JF - Current Science
SN - 0011-3891
IS - 6
ER -