Proton-decoupled 31P chemical shift imaging of the human brain in normal volunteers.

J. Murphy-Boesch, Radka Stoyanova, R. Srinivasan, T. Willard, D. Vigneron, S. Nelson, J. S. Taylor, T. R. Brown

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Proton-decoupled, 31P three-dimensional (3-D) chemical shift imaging (CSI) spectra have been acquired from the entire human brain using a new dual tuned resonator. The resonator operates in quadrature mode to provide improved sensitivity, excellent B1 homogeneity and reduced power deposition at both frequencies. Proton-decoupled and fully NOE enhanced, 31P spectra were acquired from normal volunteers using Waltz-4 proton decoupling with continuous wave bi-level excitation applied through a second radio frequency channel. Well resolved peaks in the phosphomonoester (PME) and phosphodiester regions were obtained from nonlocalized FIDs and spectra localized with 3-D CSI without processing for resolution enhancement. pH measurements made over large regions of the brain using the P(i) resonance show no significant variations (6.9 +/- 0.02) for a single individual. The improved spectral resolution and sensitivity of the PME resonances results in more well defined metabolite images of the PME peak region.

Original languageEnglish
Pages (from-to)173-180
Number of pages8
JournalNMR in Biomedicine
Volume6
Issue number3
StatePublished - May 1 1993
Externally publishedYes

Fingerprint

Protons
Brain
Healthy Volunteers
Magnetic Resonance Imaging
Resonators
Spectral resolution
Metabolites
Radio
Processing

ASJC Scopus subject areas

  • Biophysics
  • Spectroscopy
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Murphy-Boesch, J., Stoyanova, R., Srinivasan, R., Willard, T., Vigneron, D., Nelson, S., ... Brown, T. R. (1993). Proton-decoupled 31P chemical shift imaging of the human brain in normal volunteers. NMR in Biomedicine, 6(3), 173-180.

Proton-decoupled 31P chemical shift imaging of the human brain in normal volunteers. / Murphy-Boesch, J.; Stoyanova, Radka; Srinivasan, R.; Willard, T.; Vigneron, D.; Nelson, S.; Taylor, J. S.; Brown, T. R.

In: NMR in Biomedicine, Vol. 6, No. 3, 01.05.1993, p. 173-180.

Research output: Contribution to journalArticle

Murphy-Boesch, J, Stoyanova, R, Srinivasan, R, Willard, T, Vigneron, D, Nelson, S, Taylor, JS & Brown, TR 1993, 'Proton-decoupled 31P chemical shift imaging of the human brain in normal volunteers.', NMR in Biomedicine, vol. 6, no. 3, pp. 173-180.
Murphy-Boesch J, Stoyanova R, Srinivasan R, Willard T, Vigneron D, Nelson S et al. Proton-decoupled 31P chemical shift imaging of the human brain in normal volunteers. NMR in Biomedicine. 1993 May 1;6(3):173-180.
Murphy-Boesch, J. ; Stoyanova, Radka ; Srinivasan, R. ; Willard, T. ; Vigneron, D. ; Nelson, S. ; Taylor, J. S. ; Brown, T. R. / Proton-decoupled 31P chemical shift imaging of the human brain in normal volunteers. In: NMR in Biomedicine. 1993 ; Vol. 6, No. 3. pp. 173-180.
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