Proteomics and systems biology in optic nerve regeneration

Sean D. Meehan, Leila Abdelrahman, Jennifer Arcuri, Kevin K. Park, Mohammad Samarah, Sanjoy K. Bhattacharya

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

We present an overview of current state of proteomic approaches as applied to optic nerve regeneration in the historical context of nerve regeneration particularly central nervous system neuronal regeneration. We present outlook pertaining to the optic nerve regeneration proteomics that the latter can extrapolate information from multi-systems level investigations. We present an account of the current need of systems level standardization for comparison of proteome from various models and across different pharmacological or biophysical treatments that promote adult neuron regeneration. We briefly overview the need for deriving knowledge from proteomics and integrating with other omics to obtain greater biological insight into process of adult neuron regeneration in the optic nerve and its potential applicability to other central nervous system neuron regeneration.

Original languageEnglish (US)
Title of host publicationProteomics and Systems Biology
EditorsRossen Donev, Tatyana Karabencheva-Christova
PublisherAcademic Press Inc.
Pages249-270
Number of pages22
ISBN (Print)9780323853194
DOIs
StatePublished - Jan 2021

Publication series

NameAdvances in Protein Chemistry and Structural Biology
Volume127
ISSN (Print)1876-1623
ISSN (Electronic)1876-1631

Keywords

  • Axon regeneration
  • Central nervous system
  • Lipidomics
  • Mass spectrometry
  • Metabolomics
  • Optic nerve regeneration
  • Proteomics
  • Vision

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry

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