Proteolytic processing regulates placental growth factor activities

Daniel C. Hoffmann, Sebastian Willenborg, Manuel Koch, Daniela Zwolanek, Stefan Müller, Ann Kathrin A Becker, Stephanie Metzger, Martin Ehrbar, Peter Kurschat, Martin Hellmich, Jeffrey A. Hubbell, Sabine A. Eming

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: The mechanisms of placental growth factor (PlGF)-mediated blood vessel formation are incompletely understood. Results: Plasmin cleaves the heparin-binding domain of PlGF-2. Conclusion: Plasmin regulates PlGF-2/Neuropilin-1-mediated tissue vascularization and growth. Significance: Plasmin-mediated carboxyl-terminal processing of VEGF family members may be considered as a principal mechanism to regulate their biological activity.

Original languageEnglish
Pages (from-to)17976-17989
Number of pages14
JournalJournal of Biological Chemistry
Volume288
Issue number25
DOIs
StatePublished - Jun 21 2013
Externally publishedYes

Fingerprint

Fibrinolysin
Intercellular Signaling Peptides and Proteins
Processing
Neuropilin-1
Blood vessels
Bioactivity
Vascular Endothelial Growth Factor A
Blood Vessels
Heparin
Tissue
Growth

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Hoffmann, D. C., Willenborg, S., Koch, M., Zwolanek, D., Müller, S., Becker, A. K. A., ... Eming, S. A. (2013). Proteolytic processing regulates placental growth factor activities. Journal of Biological Chemistry, 288(25), 17976-17989. https://doi.org/10.1074/jbc.M113.451831

Proteolytic processing regulates placental growth factor activities. / Hoffmann, Daniel C.; Willenborg, Sebastian; Koch, Manuel; Zwolanek, Daniela; Müller, Stefan; Becker, Ann Kathrin A; Metzger, Stephanie; Ehrbar, Martin; Kurschat, Peter; Hellmich, Martin; Hubbell, Jeffrey A.; Eming, Sabine A.

In: Journal of Biological Chemistry, Vol. 288, No. 25, 21.06.2013, p. 17976-17989.

Research output: Contribution to journalArticle

Hoffmann, DC, Willenborg, S, Koch, M, Zwolanek, D, Müller, S, Becker, AKA, Metzger, S, Ehrbar, M, Kurschat, P, Hellmich, M, Hubbell, JA & Eming, SA 2013, 'Proteolytic processing regulates placental growth factor activities', Journal of Biological Chemistry, vol. 288, no. 25, pp. 17976-17989. https://doi.org/10.1074/jbc.M113.451831
Hoffmann DC, Willenborg S, Koch M, Zwolanek D, Müller S, Becker AKA et al. Proteolytic processing regulates placental growth factor activities. Journal of Biological Chemistry. 2013 Jun 21;288(25):17976-17989. https://doi.org/10.1074/jbc.M113.451831
Hoffmann, Daniel C. ; Willenborg, Sebastian ; Koch, Manuel ; Zwolanek, Daniela ; Müller, Stefan ; Becker, Ann Kathrin A ; Metzger, Stephanie ; Ehrbar, Martin ; Kurschat, Peter ; Hellmich, Martin ; Hubbell, Jeffrey A. ; Eming, Sabine A. / Proteolytic processing regulates placental growth factor activities. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 25. pp. 17976-17989.
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