Protein Synthesis Inhibitors Attenuate Seizures Induced in Rats by Lithium Plus Pilocarpine

Mary B. Williams, Richard S. Jope

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The effects of two protein synthesis inhibitors, cycloheximide and anisomycin, were tested on seizures induced by coadministration of lithium and pilocarpine to rats. Systemic cycloheximide (2 mg/kg, sc) and centrally administered anisomycin (300 μg/10 μ1, icv) doubled the latency to initiation of seizures and to status epilepticus, while peripherally administered anisomycin (50 mg/kg, sc) completely blocked lithiumpilocarpine seizures. These results indicate that protein synthesis is required for initiation of seizures.

Original languageEnglish (US)
Pages (from-to)169-173
Number of pages5
JournalExperimental Neurology
Volume129
Issue number1
DOIs
StatePublished - Sep 1994
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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