Protein Synthesis Inhibitors Attenuate Seizures Induced in Rats by Lithium Plus Pilocarpine

Mary B. Williams; Richard S. Jope

doi:10.1006/exnr.1994.1158

Protein Synthesis Inhibitors Attenuate Seizures Induced in Rats by Lithium Plus Pilocarpine

Mary B. Williams, Richard S. Jope

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The effects of two protein synthesis inhibitors, cycloheximide and anisomycin, were tested on seizures induced by coadministration of lithium and pilocarpine to rats. Systemic cycloheximide (2 mg/kg, sc) and centrally administered anisomycin (300 μg/10 μ1, icv) doubled the latency to initiation of seizures and to status epilepticus, while peripherally administered anisomycin (50 mg/kg, sc) completely blocked lithiumpilocarpine seizures. These results indicate that protein synthesis is required for initiation of seizures.

Original language	English (US)
Pages (from-to)	169-173
Number of pages	5
Journal	Experimental Neurology
Volume	129
Issue number	1
DOIs	https://doi.org/10.1006/exnr.1994.1158
State	Published - Sep 1994
Externally published	Yes

ASJC Scopus subject areas

Neurology
Developmental Neuroscience

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abstract = "The effects of two protein synthesis inhibitors, cycloheximide and anisomycin, were tested on seizures induced by coadministration of lithium and pilocarpine to rats. Systemic cycloheximide (2 mg/kg, sc) and centrally administered anisomycin (300 μg/10 μ1, icv) doubled the latency to initiation of seizures and to status epilepticus, while peripherally administered anisomycin (50 mg/kg, sc) completely blocked lithiumpilocarpine seizures. These results indicate that protein synthesis is required for initiation of seizures.",

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