Protein synthesis inhibitors attenuate seizures induced in rats by lithium plus pilocarpine

M. B. Williams, Richard S Jope

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The effects of two protein synthesis inhibitors, cycloheximide and anisomycin, were tested on seizures induced by coadministration of lithium and pilocarpine to rats. Systemic cycloheximide (2 mg/kg, sc) and centrally administered anisomycin (300 μg/10 μ1, icv) doubled the latency to initiation of seizures and to status epilepticus, while peripherally administered anisomycin (50 mg/kg, sc) completely blocked lithiumpilocarpine seizures. These results indicate that protein synthesis is required for initiation of seizures.

Original languageEnglish
Pages (from-to)169-173
Number of pages5
JournalExperimental Neurology
Volume129
Issue number1
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

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Pilocarpine
Protein Synthesis Inhibitors
Anisomycin
Lithium
Seizures
Cycloheximide
Status Epilepticus
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology

Cite this

Protein synthesis inhibitors attenuate seizures induced in rats by lithium plus pilocarpine. / Williams, M. B.; Jope, Richard S.

In: Experimental Neurology, Vol. 129, No. 1, 01.01.1994, p. 169-173.

Research output: Contribution to journalArticle

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