The effects of two protein synthesis inhibitors, cycloheximide and anisomycin, were tested on seizures induced by coadministration of lithium and pilocarpine to rats. Systemic cycloheximide (2 mg/kg, sc) and centrally administered anisomycin (300 μg/10 μ1, icv) doubled the latency to initiation of seizures and to status epilepticus, while peripherally administered anisomycin (50 mg/kg, sc) completely blocked lithiumpilocarpine seizures. These results indicate that protein synthesis is required for initiation of seizures.
ASJC Scopus subject areas
- Developmental Neuroscience