TY - JOUR
T1 - Protein Synthesis Inhibitors Attenuate Seizures Induced in Rats by Lithium Plus Pilocarpine
AU - Williams, Mary B.
AU - Jope, Richard S.
PY - 1994/9
Y1 - 1994/9
N2 - The effects of two protein synthesis inhibitors, cycloheximide and anisomycin, were tested on seizures induced by coadministration of lithium and pilocarpine to rats. Systemic cycloheximide (2 mg/kg, sc) and centrally administered anisomycin (300 μg/10 μ1, icv) doubled the latency to initiation of seizures and to status epilepticus, while peripherally administered anisomycin (50 mg/kg, sc) completely blocked lithiumpilocarpine seizures. These results indicate that protein synthesis is required for initiation of seizures.
AB - The effects of two protein synthesis inhibitors, cycloheximide and anisomycin, were tested on seizures induced by coadministration of lithium and pilocarpine to rats. Systemic cycloheximide (2 mg/kg, sc) and centrally administered anisomycin (300 μg/10 μ1, icv) doubled the latency to initiation of seizures and to status epilepticus, while peripherally administered anisomycin (50 mg/kg, sc) completely blocked lithiumpilocarpine seizures. These results indicate that protein synthesis is required for initiation of seizures.
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U2 - 10.1006/exnr.1994.1158
DO - 10.1006/exnr.1994.1158
M3 - Article
C2 - 7925839
AN - SCOPUS:0027945664
VL - 129
SP - 169
EP - 173
JO - Experimental Neurology
JF - Experimental Neurology
SN - 0014-4886
IS - 1
ER -