Abstract
The effects of two protein synthesis inhibitors, cycloheximide and anisomycin, were tested on seizures induced by coadministration of lithium and pilocarpine to rats. Systemic cycloheximide (2 mg/kg, sc) and centrally administered anisomycin (300 μg/10 μ1, icv) doubled the latency to initiation of seizures and to status epilepticus, while peripherally administered anisomycin (50 mg/kg, sc) completely blocked lithiumpilocarpine seizures. These results indicate that protein synthesis is required for initiation of seizures.
| Original language | English |
|---|---|
| Pages (from-to) | 169-173 |
| Number of pages | 5 |
| Journal | Experimental Neurology |
| Volume | 129 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1994 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
- Neurology
Cite this
Protein synthesis inhibitors attenuate seizures induced in rats by lithium plus pilocarpine. / Williams, M. B.; Jope, Richard S.
In: Experimental Neurology, Vol. 129, No. 1, 01.01.1994, p. 169-173.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Protein synthesis inhibitors attenuate seizures induced in rats by lithium plus pilocarpine
AU - Williams, M. B.
AU - Jope, Richard S
PY - 1994/1/1
Y1 - 1994/1/1
N2 - The effects of two protein synthesis inhibitors, cycloheximide and anisomycin, were tested on seizures induced by coadministration of lithium and pilocarpine to rats. Systemic cycloheximide (2 mg/kg, sc) and centrally administered anisomycin (300 μg/10 μ1, icv) doubled the latency to initiation of seizures and to status epilepticus, while peripherally administered anisomycin (50 mg/kg, sc) completely blocked lithiumpilocarpine seizures. These results indicate that protein synthesis is required for initiation of seizures.
AB - The effects of two protein synthesis inhibitors, cycloheximide and anisomycin, were tested on seizures induced by coadministration of lithium and pilocarpine to rats. Systemic cycloheximide (2 mg/kg, sc) and centrally administered anisomycin (300 μg/10 μ1, icv) doubled the latency to initiation of seizures and to status epilepticus, while peripherally administered anisomycin (50 mg/kg, sc) completely blocked lithiumpilocarpine seizures. These results indicate that protein synthesis is required for initiation of seizures.
UR - http://www.scopus.com/inward/record.url?scp=0027945664&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027945664&partnerID=8YFLogxK
U2 - 10.1006/exnr.1994.1158
DO - 10.1006/exnr.1994.1158
M3 - Article
C2 - 7925839
AN - SCOPUS:0027945664
VL - 129
SP - 169
EP - 173
JO - Experimental Neurology
JF - Experimental Neurology
SN - 0014-4886
IS - 1
ER -