Abstract
The effects of two protein synthesis inhibitors, cycloheximide and anisomycin, were tested on seizures induced by coadministration of lithium and pilocarpine to rats. Systemic cycloheximide (2 mg/kg, sc) and centrally administered anisomycin (300 μg/10 μ1, icv) doubled the latency to initiation of seizures and to status epilepticus, while peripherally administered anisomycin (50 mg/kg, sc) completely blocked lithiumpilocarpine seizures. These results indicate that protein synthesis is required for initiation of seizures.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 169-173 |
| Number of pages | 5 |
| Journal | Experimental Neurology |
| Volume | 129 |
| Issue number | 1 |
| DOIs | |
| State | Published - Sep 1994 |
| Externally published | Yes |
ASJC Scopus subject areas
- Neurology
- Developmental Neuroscience
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Cite this
Williams, M. B., & Jope, R. S. (1994). Protein Synthesis Inhibitors Attenuate Seizures Induced in Rats by Lithium Plus Pilocarpine. Experimental Neurology, 129(1), 169-173. https://doi.org/10.1006/exnr.1994.1158