Protein-protein interactions of human viruses

Norman Goodacre, Prajwal Devkota, Eunhae Bae, Stefan Wuchty, Peter Uetz

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Viruses infect their human hosts by a series of interactions between viral and host proteins, indicating that detailed knowledge of such virus-host interaction interfaces are critical for our understanding of viral infection mechanisms, disease etiology and the development of new drugs. In this review, we primarily survey human host-virus interaction data that are available from public databases following the standardized PSI-MS format. Notably, available host-virus protein interaction information is strongly biased toward a small number of virus families including herpesviridae, papillomaviridae, orthomyxoviridae and retroviridae. While we explore the reliability and relevance of these protein interactions we also survey the current knowledge about viruses functional and topological targets. Furthermore, we assess emerging frontiers of host-virus protein interaction research, focusing on protein interaction interfaces of hosts that are infected by different viruses and viruses that infect multiple hosts. Finally, we cover the current status of research that investigates the relationships of virus-targeted host proteins to other comorbidities as well as the influence of host-virus protein interactions on human metabolism.

Original languageEnglish (US)
JournalSeminars in Cell and Developmental Biology
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Viruses
Proteins
Papillomaviridae
Herpesviridae
Viral Proteins
Virus Diseases
Retroviridae
Orthomyxoviridae
Research
Comorbidity
Databases
Pharmaceutical Preparations

Keywords

  • Burden of disease
  • Interaction databases
  • Phage
  • Protein interaction network

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Protein-protein interactions of human viruses. / Goodacre, Norman; Devkota, Prajwal; Bae, Eunhae; Wuchty, Stefan; Uetz, Peter.

In: Seminars in Cell and Developmental Biology, 01.01.2018.

Research output: Contribution to journalArticle

Goodacre, Norman ; Devkota, Prajwal ; Bae, Eunhae ; Wuchty, Stefan ; Uetz, Peter. / Protein-protein interactions of human viruses. In: Seminars in Cell and Developmental Biology. 2018.
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