Protein Kinases in Cerebral Ischemia

Research output: Chapter in Book/Report/Conference proceedingChapter


Posttranslational modifications of proteins play an important role in cellular signal transduction as those modifications may alter activity/function of their respective proteins. Protein phosphorylation is one of the important posttranslational modifications, and protein kinases are a major group of proteins responsible for protein phosphorylation. The goal of this chapter is to provide an overview of how protein kinases contribute to signal transduction during the induction of ischemia tolerance and during damage following cerebral ischemia. We will focus on three groups of protein kinases, namely, protein kinase A, protein kinase B (Akt), and protein kinase C. Considering their roles in ischemia tolerance and cerebral ischemic damage, future studies intended to modulate signaling of these protein kinases may ultimately help improve outcomes in patients with stroke.

Original languageEnglish (US)
Title of host publicationPrimer on Cerebrovascular Diseases
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages5
ISBN (Print)9780128030585
StatePublished - Mar 7 2017


  • Akt
  • CAMP-dependent protein kinase
  • Ischemic tolerance
  • PKC-Delta
  • PKC-Epsilon

ASJC Scopus subject areas

  • Neuroscience(all)


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