Protein extravasation and cellular uptake after high-dose human-albumin treatment of transient focal cerebral ischemia in rats

Michel Remmers, Rainald Schmidt-Kastner, Ludmila Belayev, Baowan Lin, Raul Busto, Myron Ginsberg

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Treatment with human albumin administered intravenously in the immediate post-ischemic period following a 2-h period of transient focal cerebral ischemia leads to a reduction of cortical infarction in rat. Immunohistochemistry with antibodies to rat immunoglobulins (IgG), rat albumin and (exogenous) human albumin was used to study blood-brain barrier changes. The degree of IgG extravasation was not changed by human-albumin treatment. Diffuse signals and uptake into necrotic neurons was seen in cortex of saline animals. In animals treated with human albumin, cortical neurons with preserved structural features had taken up human albumin. Treatment with human albumin may provide direct neuronal protection.

Original languageEnglish
Pages (from-to)237-242
Number of pages6
JournalBrain Research
Volume827
Issue number1-2
DOIs
StatePublished - May 8 1999

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Transient Ischemic Attack
Albumins
Proteins
Therapeutics
Immunoglobulin G
Neurons
Blood-Brain Barrier
Infarction
Immunoglobulins
Immunohistochemistry
Antibodies

Keywords

  • Blood-brain barrier
  • Immunohistochemistry
  • Infarction
  • Stroke

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Protein extravasation and cellular uptake after high-dose human-albumin treatment of transient focal cerebral ischemia in rats. / Remmers, Michel; Schmidt-Kastner, Rainald; Belayev, Ludmila; Lin, Baowan; Busto, Raul; Ginsberg, Myron.

In: Brain Research, Vol. 827, No. 1-2, 08.05.1999, p. 237-242.

Research output: Contribution to journalArticle

Remmers, Michel ; Schmidt-Kastner, Rainald ; Belayev, Ludmila ; Lin, Baowan ; Busto, Raul ; Ginsberg, Myron. / Protein extravasation and cellular uptake after high-dose human-albumin treatment of transient focal cerebral ischemia in rats. In: Brain Research. 1999 ; Vol. 827, No. 1-2. pp. 237-242.
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