Protein extravasation and cellular uptake after high-dose human-albumin treatment of transient focal cerebral ischemia in rats

Michel Remmers, Rainald Schmidt-Kastner, Ludmila Belayev, Baowan Lin, Raul Busto, Myron D. Ginsberg

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Treatment with human albumin administered intravenously in the immediate post-ischemic period following a 2-h period of transient focal cerebral ischemia leads to a reduction of cortical infarction in rat. Immunohistochemistry with antibodies to rat immunoglobulins (IgG), rat albumin and (exogenous) human albumin was used to study blood-brain barrier changes. The degree of IgG extravasation was not changed by human-albumin treatment. Diffuse signals and uptake into necrotic neurons was seen in cortex of saline animals. In animals treated with human albumin, cortical neurons with preserved structural features had taken up human albumin. Treatment with human albumin may provide direct neuronal protection.

Original languageEnglish (US)
Pages (from-to)237-242
Number of pages6
JournalBrain Research
Volume827
Issue number1-2
DOIs
StatePublished - May 8 1999

Keywords

  • Blood-brain barrier
  • Immunohistochemistry
  • Infarction
  • Stroke

ASJC Scopus subject areas

  • Neuroscience(all)

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