Protective role of magnesium in catecholamine-induced arrhythmia and toxicity in vitro.

Martin Zdanowicz, M. A. Barletta

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The present study examined the arrhythmogenic and toxic liability of isoprenaline, noradrenaline and adrenaline using a model of spontaneously beating, cultured rat cardiomyocytes. The cardioprotective role of magnesium (Mg) was also evaluated. Following two hours of exposure to 0.1-2.7 mM doses of isoprenaline, noradrenaline or adrenaline, there were dose-dependent increases in the incidence of arrhythmia and decreases in beating activity. Myocyte LDH release increased 64-189% while total myocyte K+ and Mg2+ decreased 13-60% at high catecholamine doses. Levels of the secondary messengers IP3 and cAMP were also increased. Equimolar Mg (0.9 mM) significantly reduced the incidence of catecholamine arrhythmia while preserving beating activity, membrane integrity and electrolyte levels. Mg proved to be in vitro a potent antiarrhythmic and cardioprotective agent which is likely to exert its beneficial effects via antagonism of calcium.

Original languageEnglish (US)
Pages (from-to)153-162
Number of pages10
JournalMagnesium research : official organ of the International Society for the Development of Research on Magnesium
Volume4
Issue number3-4
StatePublished - Sep 1991
Externally publishedYes

Fingerprint

Magnesium
Catecholamines
Toxicity
Cardiac Arrhythmias
Isoproterenol
Muscle Cells
Epinephrine
Norepinephrine
Cardiotonic Agents
Poisons
Incidence
Cardiac Myocytes
Electrolytes
Rats
Calcium
Membranes
In Vitro Techniques

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

@article{1b20aa484f8148bbacd72fc070404a60,
title = "Protective role of magnesium in catecholamine-induced arrhythmia and toxicity in vitro.",
abstract = "The present study examined the arrhythmogenic and toxic liability of isoprenaline, noradrenaline and adrenaline using a model of spontaneously beating, cultured rat cardiomyocytes. The cardioprotective role of magnesium (Mg) was also evaluated. Following two hours of exposure to 0.1-2.7 mM doses of isoprenaline, noradrenaline or adrenaline, there were dose-dependent increases in the incidence of arrhythmia and decreases in beating activity. Myocyte LDH release increased 64-189{\%} while total myocyte K+ and Mg2+ decreased 13-60{\%} at high catecholamine doses. Levels of the secondary messengers IP3 and cAMP were also increased. Equimolar Mg (0.9 mM) significantly reduced the incidence of catecholamine arrhythmia while preserving beating activity, membrane integrity and electrolyte levels. Mg proved to be in vitro a potent antiarrhythmic and cardioprotective agent which is likely to exert its beneficial effects via antagonism of calcium.",
author = "Martin Zdanowicz and Barletta, {M. A.}",
year = "1991",
month = "9",
language = "English (US)",
volume = "4",
pages = "153--162",
journal = "Magnesium Research",
issn = "0953-1424",
publisher = "John Libbey Eurotext",
number = "3-4",

}

TY - JOUR

T1 - Protective role of magnesium in catecholamine-induced arrhythmia and toxicity in vitro.

AU - Zdanowicz, Martin

AU - Barletta, M. A.

PY - 1991/9

Y1 - 1991/9

N2 - The present study examined the arrhythmogenic and toxic liability of isoprenaline, noradrenaline and adrenaline using a model of spontaneously beating, cultured rat cardiomyocytes. The cardioprotective role of magnesium (Mg) was also evaluated. Following two hours of exposure to 0.1-2.7 mM doses of isoprenaline, noradrenaline or adrenaline, there were dose-dependent increases in the incidence of arrhythmia and decreases in beating activity. Myocyte LDH release increased 64-189% while total myocyte K+ and Mg2+ decreased 13-60% at high catecholamine doses. Levels of the secondary messengers IP3 and cAMP were also increased. Equimolar Mg (0.9 mM) significantly reduced the incidence of catecholamine arrhythmia while preserving beating activity, membrane integrity and electrolyte levels. Mg proved to be in vitro a potent antiarrhythmic and cardioprotective agent which is likely to exert its beneficial effects via antagonism of calcium.

AB - The present study examined the arrhythmogenic and toxic liability of isoprenaline, noradrenaline and adrenaline using a model of spontaneously beating, cultured rat cardiomyocytes. The cardioprotective role of magnesium (Mg) was also evaluated. Following two hours of exposure to 0.1-2.7 mM doses of isoprenaline, noradrenaline or adrenaline, there were dose-dependent increases in the incidence of arrhythmia and decreases in beating activity. Myocyte LDH release increased 64-189% while total myocyte K+ and Mg2+ decreased 13-60% at high catecholamine doses. Levels of the secondary messengers IP3 and cAMP were also increased. Equimolar Mg (0.9 mM) significantly reduced the incidence of catecholamine arrhythmia while preserving beating activity, membrane integrity and electrolyte levels. Mg proved to be in vitro a potent antiarrhythmic and cardioprotective agent which is likely to exert its beneficial effects via antagonism of calcium.

UR - http://www.scopus.com/inward/record.url?scp=0026212671&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026212671&partnerID=8YFLogxK

M3 - Article

VL - 4

SP - 153

EP - 162

JO - Magnesium Research

JF - Magnesium Research

SN - 0953-1424

IS - 3-4

ER -