Protective role of DC-SIGN (CD209) neck-region alleles with <5 repeat units in HIV-1 transmission

Jing Zhang, Xinsheng Zhang, Jihua Fu, Zhenqiang Bi, Kristopher L. Arheart, Luis B. Barreiro, Lluis Quintana-Murci, Savita Pahwa, Huanliang Liu

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

To investigate the role that DC-SIGN neck-region length variation plays in HIV-1 transmission, we studied 530 HIV-1-positive and 341 HIV-1-negative individuals in China. The carrier frequency of a DC-SIGN allele with <5 repeat units in the neck-region was 0.9% in HIV-1-positive and 3.8% in HIV-1-negative individuals (P = .007), an observation suggesting that this DC-SIGN variation plays a role in HIV-1 transmission. These naturally occurring DC-SIGN neck-region variants were significantly more frequent in the Chinese population than in the US population (P < .001) and in a worldwide population (P = .006).

Original languageEnglish (US)
Pages (from-to)68-71
Number of pages4
JournalJournal of Infectious Diseases
Volume198
Issue number1
DOIs
StatePublished - Jul 1 2008

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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