Protective immunity induced by live attenuated simian immunodeficiency virus

R. Paul Johnson, Ronald C. Desrosiers

Research output: Contribution to journalArticlepeer-review

116 Scopus citations


Lack of information on the mechanisms of protective immunity to AIDS virus infection represents a major obstacle to the development of a rational strategy for an effective HIV vaccine. In macaques, immunization with live attenuated simian immunodeficiency viruses has induced the most potent protective immunity and continued study promises a better understanding of the nature of protective immune responses. Recent evidence supports involvement of both cytotoxic T lymphocytes and neutralizing antibodies in protective immunity against infection by simian immunodeficiency virus, but more detailed studies are needed to document their relative importance.

Original languageEnglish (US)
Pages (from-to)436-443
Number of pages8
JournalCurrent Opinion in Immunology
Issue number4
StatePublished - Aug 1998
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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