Protective effects of prostaglandin E1 on acute lung injury of caerulein-induced acute pancreatitis in rats

Kenji Yamanaka, Ashok Saluja, Glenn E. Brown, Yoshikazu Yamaguchi, Bernd Hofbauer, Michael L. Steer

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Infusion of a supramaximally stimulating dose of the pancreatic secretagogue caerulein (10 μg · kg-1 · h-1) for 4 h induces interstitial edematous acute pancreatitis in rats. This model of acute pancreatitis is associated with evidence of acute lung injury, including sequestered neutrophils within the pulmonary microvasculature, increased microvascular permeability, and interstitial pulmonary edema. Infusion of prostaglandin E1 (PGE1; 50 ng · kg-1 · min-1) along with caerulein does not alter the severity of secretagogue-induced pancreatitis, but it does reduce the severity of pancreatitis-associated acute lung injury. The rise in lung weight, lung water content, and pulmonary microvascular permeability and the sequestration of neutrophils within the pulmonary microvasculature that accompany secretagogue-induced pancreatitis are all reduced by infusion of PGE1. Infusion of PGE1 does not interfere with polymorphonuclear neutrophil sequestration in the pancreas or reduce the enhanced expression of CD11b/c receptors on circulating neutrophils. Our observations indicate that PGE1 reduces the severity of pancreatitis-associated acute lung injury by preventing neutrophil sequestration within the lung. We speculate that PGE1 interferes with neutrophil sequestration by dilating pulmonary vasculature, increasing pulmonary flow rate, and reducing neutrophil-endothelial cell interaction and attachment.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume272
Issue number1 35-1
StatePublished - Jan 1 1997
Externally publishedYes

Fingerprint

Ceruletide
Acute Lung Injury
Alprostadil
Pancreatitis
Neutrophils
Lung
Capillary Permeability
Microvessels
Bronchopulmonary Sequestration
Pulmonary Edema
Cell Communication
Pancreas
Endothelial Cells
Weights and Measures
Water

Keywords

  • adult respiratory distress syndrome
  • CD11b/c
  • fluorescein isothiocyanate albumin
  • myeloperoxidase
  • neutrophil

ASJC Scopus subject areas

  • Physiology
  • Hepatology
  • Gastroenterology
  • Physiology (medical)

Cite this

Protective effects of prostaglandin E1 on acute lung injury of caerulein-induced acute pancreatitis in rats. / Yamanaka, Kenji; Saluja, Ashok; Brown, Glenn E.; Yamaguchi, Yoshikazu; Hofbauer, Bernd; Steer, Michael L.

In: American Journal of Physiology - Gastrointestinal and Liver Physiology, Vol. 272, No. 1 35-1, 01.01.1997.

Research output: Contribution to journalArticle

Yamanaka, Kenji ; Saluja, Ashok ; Brown, Glenn E. ; Yamaguchi, Yoshikazu ; Hofbauer, Bernd ; Steer, Michael L. / Protective effects of prostaglandin E1 on acute lung injury of caerulein-induced acute pancreatitis in rats. In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 1997 ; Vol. 272, No. 1 35-1.
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