Protection of vaccinia-primed macaques against SIVmne infection by combination immunization with recombinant vaccinia virus and SIVmne gp160.

S. L. Hu, V. Stallard, K. Abrams, Glen N Barber, L. Kuller, A. J. Langlois, W. R. Morton, R. E. Benveniste

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21 Scopus citations

Abstract

Two Macaca fascicularis with preexisting immunity to vaccinia virus were immunized twice with recombinant vaccinia virus expressing SIVmne gp160. Their SIV-specific antibody responses were lower than that of vaccinia-naive animals immunized similarly. Upon repeated boosting with gp160, the SIV-specific antibody titers in vaccinia-primed animals reached similar levels as vaccinia-naive animals and with comparable neutralizing titers. Both animals were protected against repeated intravenous challenge with low-dose SIVmne E11S. These results are significant because SIVmne E11S infection in M. fascicularis is pathogenic and leads to AIDS-like diseases.

Original languageEnglish
Pages (from-to)92-99
Number of pages8
JournalJournal of Medical Primatology
Volume22
Issue number2-3
StatePublished - Feb 1 1993
Externally publishedYes

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ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Hu, S. L., Stallard, V., Abrams, K., Barber, G. N., Kuller, L., Langlois, A. J., Morton, W. R., & Benveniste, R. E. (1993). Protection of vaccinia-primed macaques against SIVmne infection by combination immunization with recombinant vaccinia virus and SIVmne gp160. Journal of Medical Primatology, 22(2-3), 92-99.