Protection of vaccinia-primed macaques against SIVmne infection by combination immunization with recombinant vaccinia virus and SIVmne gp160.

S. L. Hu, V. Stallard, K. Abrams, G. N. Barber, L. Kuller, A. J. Langlois, W. R. Morton, R. E. Benveniste

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22 Scopus citations

Abstract

Two Macaca fascicularis with preexisting immunity to vaccinia virus were immunized twice with recombinant vaccinia virus expressing SIVmne gp160. Their SIV-specific antibody responses were lower than that of vaccinia-naive animals immunized similarly. Upon repeated boosting with gp160, the SIV-specific antibody titers in vaccinia-primed animals reached similar levels as vaccinia-naive animals and with comparable neutralizing titers. Both animals were protected against repeated intravenous challenge with low-dose SIVmne E11S. These results are significant because SIVmne E11S infection in M. fascicularis is pathogenic and leads to AIDS-like diseases.

Original languageEnglish (US)
Pages (from-to)92-99
Number of pages8
JournalJournal of medical primatology
Volume22
Issue number2-3
StatePublished - Jan 1 1993
Externally publishedYes

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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    Hu, S. L., Stallard, V., Abrams, K., Barber, G. N., Kuller, L., Langlois, A. J., Morton, W. R., & Benveniste, R. E. (1993). Protection of vaccinia-primed macaques against SIVmne infection by combination immunization with recombinant vaccinia virus and SIVmne gp160. Journal of medical primatology, 22(2-3), 92-99.