Protection of lethally irradiated guinea pigs with fresh and frozen homologous peripheral blood leukocytes

Vernon P. Perry, Theodore I. Malinin, Carey C. Kerby, Michael F. Dolan

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Lethally irradiated (550 r Co60) Princeton guinea pigs can survive beyond a 30-day period following the early postirradiation infusion of adequate numbers of either fresh (1 × 108) or frozen (1 × 109) homologous peripheral blood leukocytes. Animals infused with larger numbers of fresh homologous cells 24 hr following radiation died, as did all control animals. Animals surviving the lethal period failed to demonstrate any gross evidence of homologous disease as late as 272 days following irradiation. A histopathological study of the surviving animals and animals sacrificed at daily intervals during the postirradiation period (the subject of a separate report) suggests that the infused cells provided a necessary transient mechanism for combating bacterial infection.

Original languageEnglish (US)
Pages (from-to)233-239
Number of pages7
JournalCryobiology
Volume1
Issue number3
DOIs
StatePublished - Jan 1 1965

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Fingerprint Dive into the research topics of 'Protection of lethally irradiated guinea pigs with fresh and frozen homologous peripheral blood leukocytes'. Together they form a unique fingerprint.

  • Cite this