Protection of lethally irradiated guinea pigs with fresh and frozen homologous peripheral blood leukocytes

Vernon P. Perry, Theodore Malinin, Carey C. Kerby, Michael F. Dolan

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Lethally irradiated (550 r Co60) Princeton guinea pigs can survive beyond a 30-day period following the early postirradiation infusion of adequate numbers of either fresh (1 × 108) or frozen (1 × 109) homologous peripheral blood leukocytes. Animals infused with larger numbers of fresh homologous cells 24 hr following radiation died, as did all control animals. Animals surviving the lethal period failed to demonstrate any gross evidence of homologous disease as late as 272 days following irradiation. A histopathological study of the surviving animals and animals sacrificed at daily intervals during the postirradiation period (the subject of a separate report) suggests that the infused cells provided a necessary transient mechanism for combating bacterial infection.

Original languageEnglish
Pages (from-to)233-239
Number of pages7
JournalCryobiology
Volume1
Issue number3
StatePublished - Jan 1 1965
Externally publishedYes

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guinea pigs
leukocytes
Guinea Pigs
Animals
Leukocytes
Blood
blood
animals
bacterial infections
Bacterial Infections
irradiation
Irradiation
cells
Radiation

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Perry, V. P., Malinin, T., Kerby, C. C., & Dolan, M. F. (1965). Protection of lethally irradiated guinea pigs with fresh and frozen homologous peripheral blood leukocytes. Cryobiology, 1(3), 233-239.

Protection of lethally irradiated guinea pigs with fresh and frozen homologous peripheral blood leukocytes. / Perry, Vernon P.; Malinin, Theodore; Kerby, Carey C.; Dolan, Michael F.

In: Cryobiology, Vol. 1, No. 3, 01.01.1965, p. 233-239.

Research output: Contribution to journalArticle

Perry, VP, Malinin, T, Kerby, CC & Dolan, MF 1965, 'Protection of lethally irradiated guinea pigs with fresh and frozen homologous peripheral blood leukocytes', Cryobiology, vol. 1, no. 3, pp. 233-239.
Perry, Vernon P. ; Malinin, Theodore ; Kerby, Carey C. ; Dolan, Michael F. / Protection of lethally irradiated guinea pigs with fresh and frozen homologous peripheral blood leukocytes. In: Cryobiology. 1965 ; Vol. 1, No. 3. pp. 233-239.
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