Lethally irradiated (550 r Co60) Princeton guinea pigs can survive beyond a 30-day period following the early postirradiation infusion of adequate numbers of either fresh (1 × 108) or frozen (1 × 109) homologous peripheral blood leukocytes. Animals infused with larger numbers of fresh homologous cells 24 hr following radiation died, as did all control animals. Animals surviving the lethal period failed to demonstrate any gross evidence of homologous disease as late as 272 days following irradiation. A histopathological study of the surviving animals and animals sacrificed at daily intervals during the postirradiation period (the subject of a separate report) suggests that the infused cells provided a necessary transient mechanism for combating bacterial infection.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)